Please use this identifier to cite or link to this item: http://www.repositorio.ufc.br/handle/riufc/18726
Title in Portuguese: Counteracting effects on free radicals and histological alterations induced by a fraction with casearins
Author: Araújo, Éverton José Ferreira de
Oliveira, Guilherme Antônio Lopes de
Sousa, Lívia Queiroz de
Bolzani, Vanderlan da Silva
Cavalheiro, Alberto José
Tomé, Adriana da Rocha
Peron, Ana Paula
Santos, André Gonzaga dos
Citó, Antonia Maria das Graças Lopes
Pessoa, Cláudia
Freitas, Rivelilson Mendes de
Ferreira, Paulo Michel Pinheiro
Keywords: Diterpenos Clerodânicos
Antioxidantes
Issue Date: Sep-2015
Publisher: Anais da Academia Brasileira de Ciências
Citation: ARAÚJO, É. J. F. de et al. Counteracting effects on free radicals and histological alterations induced by a fraction with casearins. Anais da Academia Brasileira de Ciências, Rio de Janeiro, v. 87, n. 3, p. 1791-1807, sept., 2015.
Abstract: Casearia sylvestris Swartz is a medicinal plant widely distributed in Brazil. It has anti-inflammatory, antiulcer and antitumor activities and is popularly used to treat snakebites, wounds, diarrhea, flu and chest colds. Its leaves are rich in oxygenated tricyclic cis -clerodane diterpenes, particulary casearins. Herein, we evaluated the antioxidant activities of a fraction with casearins (FC) isolated from C. sylvestris and histological changes on the central nervous system and livers of Mus musculus mice. Firstly, in vitro studies (0.9, 1.8, 3.6, 5.4 and 7.2 μg/mL) revealed EC 50 values of 3.7, 6.4 and 0.16 μg/mL for nitrite, hydroxyl radical and TBARS levels, respectively. Secondly, FC (2.5, 5, 10 and 25 mg/kg/day) was intraperitoneally administered to Swiss mice for 7 consecutive days. Nitrite levels in the hippocampus (26.2, 27.3, 30.2 and 26.6 μM) and striatum (26.3, 25.4, 34.3 and 27.5 μM) increased in all treated animals (P < 0.05). Lower doses dropped reduced glutathione, catalase and TBARS levels in the hippocampus and striatum. With the exception of this reduction in TBARS formation, FC displayed only in vitro antioxidant activity. Animals exhibited histological alterations suggestive of neurotoxicity and hepatotoxicity, indicating the need for precaution regarding the consumption of medicinal formulations based on Casearia sylvestris .
URI: http://www.repositorio.ufc.br/handle/riufc/18726
metadata.dc.type: Artigo de Periódico
ISSN: Printed version ISSN 0001-3765
Online version ISSN 1678-2690
Appears in Collections:PPGF - Artigos publicados em revistas científica

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