Use este identificador para citar ou linkar para este item: http://www.repositorio.ufc.br/handle/riufc/18740
Título: Conformational variability in sulfonamide chalcone hybrids : crystal structure and cytotoxicity
Autor(es): Castro, Mirian R. C. de
Aragão, Ângelo Q.
Silva, Cameron C. da
Perez, Caridad N.
Queiroz, Darlene P. K.
Queiroz Júnior, Luiz Henrique K.
Barreto, Stefânio
Moraes, Manoel O. de
Martins, Felipe Terra
Palavras-chave: Estrutura Molecular
Calcona
Data do documento: 2016
Editor: Journal of the Brazilian Chemical Society
Citação: CASTRO, M. R. C. ; ARAGÃO, Â. Q. ; SILVA, C. C. ; PEREZ, C. N. ; QUEIROZ, D. P. K. ; QUEIROZ JÚNIOR, L. H. K. ; BARRETO, S. ; MORAES, M. O. ; MARTIN, F. T. (2016)
Abstract: Four sulfonamide-chalcone derivatives were prepared and their crystal structure were elucidated by single-crystal X-ray diffraction technique. They were synthesized by Claisen-Schmidt condensation reaction between N -(4-acetylphenyl)benzenesulfonamide or N -(4-acetylphenyl)- 2,5-dichlorobenzenesulfonamide with benzaldehyde or p -nitrobenzaldehyde. Values of Z’ > 1 are found in three compounds as a consequence of conformerism. The chalcone molecular backbones are featured by different levels of planarity in their conformers. Another conformational variability is in its benzenesulfonamide moiety. In the compound came from N -(4-acetylphenyl) benzenesulfonamide and benzaldehyde, there is a rotation of ca. 180° on the bond axis bridging the sulfonamide and chalcone motifs of one conformer if the two others are taken as references. The cytotoxic activity of all compounds synthesized here and of two other related sulfonamide chalcones was also assessed against three cancer cell lines (SF-295, HCT-8 and MDA-MB-435). The para -nitro compounds were the most active ones among all those tested, regardless of substitution pattern in benzenesulfonamide core.
Descrição: CASTRO, Mirian R. C. de et al. Conformational variability in sulfonamide chalcone hybrids : crystal structure and cytotoxicity. Journal of the Brazilian Chemical Society, São Paulo, v. 27, n. 5, p. 884-898, 2016.
URI: http://www.repositorio.ufc.br/handle/riufc/18740
ISSN: Impresso 0103-5053
On-line 1678-4790
Aparece nas coleções:DFIFA - Artigos publicados em revista científica

Arquivos associados a este item:
Arquivo Descrição TamanhoFormato 
2016_art_mrccastro.pdf4,65 MBAdobe PDFVisualizar/Abrir


Os itens no repositório estão protegidos por copyright, com todos os direitos reservados, salvo quando é indicado o contrário.