Use este identificador para citar ou linkar para este item: http://www.repositorio.ufc.br/handle/riufc/18784
Título: Genotoxicity and DNA repair indicative in blood cells after occupational exposure to ionizing radiation
Autor(es): Silva, Ronald Gerard
Alencar, Marcus Vinícius Oliveira Barros
Teixeira, Jadson Silva T
Silva, Reyca Rodrigues e
Paz, Márcia Fernanda Correia Jardim
Sousa, João Marcelo de Castro e
Mata, Ana Maria Oliveira Ferreira da
Santos, José Victor de Oliveira
Islam, Torequl
Ferreira, Paulo Michel Pinheiro
Melo-Cavalcante, Ana Amélia de Carvalho
Picada, Jaqueline Nascimento
Palavras-chave: Radiação Ionizante
Ionizing Radiation
Reparo do DNA
Data do documento: 2016
Editor: International Archives of Medicine
Citação: SILVA, R. G. ; ALENCAR, M. V. O. B. ; TEIXEIRA, J.S. ; SILVA, R. R. ; PAZ, M. F. C. J. ; SOUSA, J. M. C. ; MATA, A. M. O. F. ; SANTOS, J. V. O. ; ISLAM, T. ; FERREIRA, P. M. P. ; MELO-CAVALCANTE, A. A. C. ; PICADA, J. N. (2016)
Abstract: Occupational exposure to ionizing radiation (IR) can damage DNA. The study evaluated the genotoxic profile and repair indicatives of DNA from peripheral blood lymphocytes of health workers exposed occupationally to IR by adopting comet assay. Biomonitoring was done with ninety individuals; among them 45 were health professionals and the rests were non-professionals. Blood samples were collected after 48 h (2 d; non-exposed) and 168 h (7 d; exposed). The 7 d IR exposed group significantly increased in the rates and frequency of damage, while 2 d unexposed group exhibited more than 20% of DNA repair as compared to the respective control groups. The DNA damage was observed in more significant to the younger workers (18-27 y). However, the hematological abnormalities were not observed, despite of their positive correlation in genotoxic profile. Significant and positive correlations were observed in relation to the used medicaments, low consumption of vegetables as well as the type and place of work. In conclusion, biomarkers involved in comet assay can be applied in biomonitoring of genetic instability, including IR induced phenomena.
Descrição: SILVA, Ronald Gerard et al. Genotoxicity and DNA repair indicative in blood cells after occupational exposure to ionizing radiation. International Archives of Medicine, London, v. 9, n. 121, p. 1-13, 2016.
URI: http://www.repositorio.ufc.br/handle/riufc/18784
ISSN: 1755-7682
Aparece nas coleções:DFIFA - Artigos publicados em revista científica

Arquivos associados a este item:
Arquivo Descrição TamanhoFormato 
2016_art_rgsilva.pdf1,1 MBAdobe PDFVisualizar/Abrir


Os itens no repositório estão protegidos por copyright, com todos os direitos reservados, salvo quando é indicado o contrário.