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Título: Pentoxifylline neuroprotective effects are possibly related to its anti-inflammatory and TNF-Alpha inhibitory properties, in the 6-OHDA model of Parkinson’s disease
Autor(es): Neves, Kelly Rose Tavares
Nobre Júnior, Hélio Vitoriano
Leal, Luzia Kalyne A. M.
Andrade, Geanne Matos de
Brito, Gerly Anne de Castro
Viana, Glauce Socorro de Barros
Palavras-chave: Doença de Parkinson
Data do documento: 2015
Editor: Parkinson's Disease
Citação: NEVES, K. R. T. ; NOBRE JR., H. V. ; LEAL, L. K. A. M. ; ANDRADE, G. M. ; BRITO, G. A. C. ; VIANA, G. S. B. (2015)
Abstract: Pentoxifylline (PTX) is a phosphodiesterase inhibitor with anti-TNF-alpha activity, associated with its anti-inflammatory action. Considering Parkinson’s disease (PD) as a neuroinflammatory disorder, the objectives were to evaluate PTX neuroprotective properties, in a model of PD. Male Wistar rats, divided into sham-operated (SO), untreated 6-OHDA, and 6-OHDA treated with PTX (10, 25, and 50 mg/kg) groups, received a unilateral 6-OHDA injection, except the SO group administered with saline. Treatments started 24 h after surgery and continued for 15 days when the animals were submitted to apomorphine-induced rotations, open field, and forced swimming tests. At the next day, they were euthanized and their striata processed for neurochemical (DA and DOPAC determinations), histological, and immunohistochemical (Fluoro-Jade, TH, DAT, OX-42, TNF-alpha, COX-2, and iNOS) studies. PTX reversed the behavioral changes observed in the untreated 6-OHDA animals. Furthermore, PTX partially reversed the decrease in DA contents and improved neuronal viability. In addition, decreases in immunostaining for TH and dopamine transporter (DAT) were reversed. The untreated 6-OHDA group showed intense OX-42, TNF-alpha, COX-2, and iNOS immunoreactivities, which were attenuated by PTX. In conclusion, we demonstrated a neuroprotective effect of PTX, possibly related to its anti-inflammatory and antioxidant actions, indicating its potential as an adjunct treatment for PD.
Descrição: NEVES, Kelly Rose Tavares et al. Pentoxifylline neuroprotective effects are possibly related to Its anti-Inflammatory and TNF-Alpha inhibitory properties, in the 6-OHDA model of Parkinson’s disease. Parkinson's Disease, v. 2015, p. 1-16, 2015.
ISSN: 2090-8083
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