Use este identificador para citar ou linkar para este item: http://www.repositorio.ufc.br/handle/riufc/19059
Título: N-acetylcysteine attenuates nicotine-induced kindling in female periadolescent rats
Autor(es): Okamura, Adriana Mary Nunes Costa
Gomes, Patrícia Xavier L.
Oliveira, Gersilene V. de
Araújo, Fernanda Yvelize R. de
Tomaz, Viviane S.
Chaves Filho, Adriano José Maia
Sousa, Francisca Cléa F. de
Vasconcelos, Silvânia Maria Mendes
Lucena, David Freitas de
Macêdo, Danielle
Palavras-chave: Psiquiatria Biológica
Excitação Neurológica
Kindling, Neurologic
Transtorno Bipolar
Data do documento: Jun-2016
Editor: Progress in Neuro-Psychopharmacology & Biological Psychiatry
Citação: OKAMURA, A. M. N. C. ; GOMES, P. X. L. ; OLIVEIRA, G. V. ; ARAÚJO, F. Y. R. ; TOMAZ, V. S. ; CHAVES FILHO, A. J. M. ; SOUSA, F. C. F. ; VASCONCELOS, S. M. M. ; LUCENA, D. F. ; MACÊDO, D. (2016)
Abstract: Kindling We recently demonstrated that female periadolescent rats are more vulnerable to nicotine (NIC)-induced kindling than their male counterparts. Furthermore, we evidenced that decreases in brain antioxidative defenses may contribute to this gender difference. Here we aimed to determine the preventive effects of the antioxidant N-acetyl cysteine (NAC) against NIC-kindling in female periadolescent rats. To do this female Wistar rats at postnatal day 30 received repeated injections of NIC 2 mg/kg, i.p. every weekday for up to 19 days. NAC90, 180 or 270 mg/kg, i.p. was administered 30 min before NIC. The levels of glutathione (GSH), superoxide dismutase (SOD) activity, lipid peroxidation (LP) and nitrite were determined in the prefrontal cortex (PFC), hippocampus (HC) and striatum (ST). The development of kindling occurred at a median time of 16.5 days with 87.5% of NIC animals presenting stage 5 seizures in the last day of drug administration. NAC270 prevented the occurrence of kindling. NIC-kindled animals presented decreased levels of GSH and increased LP in the PFC, HC and ST, while SOD activity was decreased in the ST. NAC180 or 270 prevented the alterations in GSH induced by NIC, but only NAC270 prevented the alterations in LP. Nitrite levels increased in the ST of NAC270 pretreated NIC-kindled animals. Taken together we demonstrated that NAC presents anti-kindling effects in female animals partially through the restoration of oxidative alterations.
Descrição: OKAMURA, Adriana Mary Nunes Costa et al. N-acetylcysteine attenuates nicotine-induced kindling in female periadolescent rats. Progress in Neuro-Psychopharmacology & Biological Psychiatry, v. 67, p. 58-65, jun. 2016.
URI: http://www.repositorio.ufc.br/handle/riufc/19059
ISSN: 0278-5846
1878-4216
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