Use este identificador para citar ou linkar para este item: http://www.repositorio.ufc.br/handle/riufc/19255
Título: Omega-3 fatty acids : possible ceuroprotective mechanisms in the model of global ischemia in rats
Autor(es): Nobre, Maria Elizabeth Pereira
Correia, Alyne Oliveira
Mendonça, Francisco Nilson Maciel
Uchoa, Luiz Ricardo Araújo
Vasconcelos, Jessica Tamara Nunes
Araújo, Carlos Ney Alencar de
Brito, Gerly Anne de Castro
Siqueira, Rafaelly Maria Pinheiro
Cerqueira, Gilberto dos Santos
Neves, Kelly Rose Tavares
Arida, Ricardo Mário
Viana, Glauce Socorro de Barros
Palavras-chave: Fármacos Neuroprotetores
Neuroprotective Agents
Isquemia
Ischemia
Data do documento: 2016
Editor: Journal of Nutrition and Metabolism
Citação: NOBRE, M. E. P. ; CORREIA, A. O. ; MENDONÇA, F. N. M. ; UCHOA, L. R. A. ; VASCONCELOS, J. T. N. ; ARAÚJO, C. N. A. ; BRITO, G. A. C. ; SIQUEIRA, R. M. P. ; CERQUEIRA, G. S. ; NEVES, K. R. T. ; ARIDA, R. M. ; VIANA, G. S. B. (2016)
Abstract: Background. Omega-3 (3) administration was shown to protect against hypoxic-ischemic injury. The objectives were to study the neuroprotective effects of 3, in a model of global ischemia. Methods. Male Wistar rats were subjected to carotid occlusion (30 min), followed by reperfusion. The groups were SO, untreated ischemic and ischemic treated rats with 3 (5 and 10 mg/kg, 7 days). The SO and untreated ischemic animals were orally treated with 1% cremophor and, 1 h after the last administration, they were behaviorally tested and euthanized for neurochemical (DA, DOPAC, and NE determinations), histological (Fluoro jade staining), and immunohistochemical (TNF-alpha, COX-2 and iNOS) evaluations. The data were analyzed by ANOVA and Newman-Keuls as the post hoc test. Results. Ischemia increased the locomotor activity and rearing behavior that were partly reversed by 3. Ischemia decreased striatal DA and DOPAC contents and increased NE contents, effects reversed by 3. This drug protected hippocampal neuron degeneration, as observed by Fluoro-Jade staining, and the increased immunostainings for TNF-alpha, COX-2, and iNOS were partly or totally blocked by 3. Conclusion. This study showed a neuroprotective effect of 3, in great part due to its anti-inflammatory properties, stimulating translational studies focusing on its use in clinic for stroke managing.
Descrição: NOBRE, Maria Elizabeth Pereira et al. Omega-3 fatty acids : possible neuroprotective mechanisms in the model of global ischemia in rats. Journal of Nutrition and Metabolism, v. 2016, p. 1-13, 2016.
URI: http://www.repositorio.ufc.br/handle/riufc/19255
ISSN: 2090-0724
2090-0732
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