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Title in Portuguese: Oil mixes omega 9, 6 and 3, enriched with seaweed, promoted reduction of thermal burned modulating NF-kB and Ki-67
Author: Campelo, Ana Paula Bomfim Soares
Campelo, Márcio Wilker Soares
Brito, Gerly Anne de Castro
Jamacaru, Francisco Vagnaldo Fechine
Leitão, Renata Ferreira de Carvalho
Vasconcelos, Paulo Roberto Leitão de
Keywords: Ácidos Graxos
Fatty Acids
Ácido alfa-linolênico
Issue Date: 2015
Publisher: Acta cirúrgica brasileira
Citation: CAMPELO, A. P. B. S. et al. Oil mixes omega 9, 6 and 3, enriched with seaweed, promoted reduction of thermal burned modulating NF-kB and Ki-67. Acta Cirúrgica Brasileira, São Paulo, v. 30, n. 6, p. 430-438, 2015.
Abstract: PURPOSE: To examine the effects of the oil mixes (ω-9, ω-6 and ω-3) in rats subjected to thermal burn. It was also aimed to assess whether the sources of ω3 would interfere with the effect of such mixes on the thermal injury. METHODS: Thirty-six rats distributed into five groups: burned + water, burned + isolipid mix, burned + oil mix 1 (ALA), burned + oil mix 2 (ALA + EPA + DHA of fish) and burned + oil mix 3 (ALA + DHA from seaweed). The thermal injury was involving total thickness of skin. After the burns animals received the oil mixes for seven days. The lesions were evaluated by immunohistochemistry. RESULTS: Animals receiving mix 3 showed a smaller extension of the thermal injury as compared to those that were supplemented with other oils mixes. Expression of Ki-67 in the receiving Mix 3 increased as compared to all the other groups. Animals supplemented with mix 3 were able to inhibit NF-κB in injured tissue. CONCLUSION: Rats received oil mix in which the source of ω3 (ALA+DHA of seaweed) showed inhibition of NF-κB, increase in cell proliferation, and reduction the extension of thermal lesion.
metadata.dc.type: Artigo de Periódico
ISSN: Impresso 0102-8650
On-line 1678-2674
Appears in Collections:PPGF - Artigos publicados em revistas científica

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