Use este identificador para citar ou linkar para este item: http://www.repositorio.ufc.br/handle/riufc/20110
Título: Antibiotic-modifying activity of riachin, a non-cyanogenic cyanoglycoside extracted from Bauhinia pentandra
Autor(es): Farias, Pablo Antonio Maia de
Figueredo, Fernando Gomes
Lucas, Aline Maria Brito
Moura, Rafael Barbosa de
Coutinho, Henrique Douglas Melo
Silva, Tania Maria Sarmento da
Martin, Ana Luiza de Aguiar Rocha
Fonteles, Marta Maria de França
Palavras-chave: Antibacterianos
Anti-Bacterial Agents
Data do documento: Jun-2015
Editor: Drug Design, Development and Therapy
Citação: FARIAS, P. A. M. ; FIGUEREDO, F. G. ; LUCAS, A. M. B. ; MOURA, R. B. ; COUTINHO, H. D. M. ; SILVA, T. M. S. ; MARTIN, A. L. A. R. ; FONTELES, M. M. F.
Abstract: Background: The search for new active compounds from the Brazilian flora has intensified in recent years, especially for new drugs with antibiotic potential. Accordingly, the aim of this study was to determine whether riachin has antibiotic activity in itself or is able to modulate the activity of conventional antibiotics. Methods: A non-cyanogenic cyanoglycoside known as riachin was isolated from Bauhinia pentandra, and was tested alone and in combination with three antibiotics (clindamycin, amikacin, and gentamicin) against multiresistant bacterial strains (Escherichia coli, Pseudomonas aeruginosa, and Staphylococcus aureus). Results: Riachin did not show significant antibiotic activity when tested alone against any strain (P.0.05). However, when combined with conventional antibiotics, it showed drugmodifying activity against strains of S. aureus exposed to clindamycin (P,0.001) as well as against P. aeruginosa exposed to amikacin (P,0.001). Although riachin did not show direct antibiotic activity, it had synergistic activity when combined with amikacin or clindamycin. The mechanism of action of this synergism is under investigation. Conclusion: The results of this work demonstrate that some substances of natural origin can enhance the effectiveness of certain antibiotics, which means a substantial reduction in the drug dose required and possibly in consequent adverse events for patients.
Descrição: FARIAS, Pablo Antonio Maia de et al. Antibiotic-modifying activity of riachin, a non-cyanogenic cyanoglycoside extracted from Bauhinia pentandra. Drug Design, Development and Therapy, v. 9, p. 3067-3072, jun. 2015.
URI: http://www.repositorio.ufc.br/handle/riufc/20110
ISSN: 1177-8881
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