Use este identificador para citar ou linkar para este item: http://www.repositorio.ufc.br/handle/riufc/20465
Título: Pancytopenia during tyrosine kinase inhibitor treatment–coexistence of chronic myeloid leukemia and visceral leishmaniasis : a case report
Autor(es): Quixada, Acy
Maia Filho, Pedro Aurio
Almeida Filho, Tarcísio Paulo
Duarte, Fernando Barroso
Moreira-Nunes, Caroline Aquino
Lemes, Romélia Pinheiro Gonçalves
Palavras-chave: Leishmaniose Visceral
Leucemia Mieloide
Leukemia, Myeloid
Proteínas Tirosina Quinases
Data do documento: 2016
Editor: Journal of Medical Case Reports
Citação: QUIXADA, A. ; MAIA FILHO, P. A. ; ALMEIDA FILHO, T. P. ; DUARTE, F. B. ; MOREIRA-NUNES, C. A. ; LEMES, R. P. G. (2016)
Abstract: Background: Visceral leishmaniasis is a zoonosis characterized by chronic evolution of symptoms; it usually appears 2 to 4 months after the initial infection, with multiple cutaneous lesions and systemic involvement, which if left untreated results in death in 90 % of cases. Case presentation: We present a case of 29-year-old white male farmer, with chronic myeloid leukemia treated with imatinib who developed significant pancytopenia, leading to discontinuation of treatment. His neutrophil count fell to 0.5 × 10 9 /L, his platelets dropped to 85 × 10 9 / μ L, and his hemoglobin was 6.4 g/dL. A bone marrow study was performed, showing complete remission of chronic myeloid leukemia and numerous Leishmania amastigotes within the macrophages. He used pentavalent antimonials replaced by amphotericin B due to acute cardiac toxicity. After 3 months, imatinib was restarted, and he again showed adequate control of the disease. The last polymerase chain reaction assessment showed a deep molecular response. Conclusion: The hypothesis of an adverse event or secondary resistance to tyrosine kinase inhibitors, with subsequent progression to advanced disease, was initially raised, although a detailed evaluation has shown that it was an associated infectious disease.
Descrição: QUIXADA, Acy et al. Pancytopenia during tyrosine kinase inhibitor treatment–coexistence of chronic myeloid leukemia and visceral leishmaniasis : a case report. Journal of Medical Case Reports, London, v. 10, p. 1-4, 2016.
URI: http://www.repositorio.ufc.br/handle/riufc/20465
ISSN: 1752-1947
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