Use este identificador para citar ou linkar para este item: http://www.repositorio.ufc.br/handle/riufc/22033
Título: Delivery system for mefenamic acid based on the nanocarrier layered double hydroxide : physicochemical characterization and evaluation of anti-inflammatory and antinociceptive potential
Autor(es): Cunha, Vanessa R. R.
Guilherme, Viviane A.
Paula, Eneida de
Araujo, Daniele R. de
Silva, Renan O.
Medeiros, Jand V. R.
Leite, José R. S. A.
Petersen, Philippe A. D.
Foldvari, Marianna
Petrilli, Helena M.
Constantino, Vera R. L.
Palavras-chave: Ácido Mefenâmico
Mefenamic Acid
Anti-Inflamatórios
Anti-Inflammatory Agents
Data do documento: Jan-2016
Editor: Materials science & engineering - C - Biomimetic materials, sensors and systems
Citação: CUNHA, V. R. R. ; GUILHERME, V. A. ; PAULA, E. ; ARAUJO, D. R. ; SILVA, R. O. ; MEDEIROS, J. V. R. ; LEITE, J. R. S. A. ; PETERSEN, P. A. D. ; FOLDVARI, M. ; PETRILLI, H. M. ; CONSTANTINO, V. R. L (2016)
Abstract: Purpose The anionic form of the drug mefenamic acid intercalated into the nanocarrier layered double hydroxide (LDH-Mef) was evaluated by anti-inflammatory and antinociceptive assays. Methods The LDH-Mef material was characterized by a set of physicochemical techniques, which was supported by Density Functional Theory calculations. The pharmacological effects of LDH-Mef (40 wt% of drug) were evaluated by hemolytic, anti-inflammatory activity and antinociceptive assays. Results In vivo assays were conducted for the first time in order to assess the LDH-Mef potential. The hemolytic effects decreased for the intercalated Mef as demonstrated by the higher tolerated hemolytic concentration (1.83 mM) compared to mefenamic acid (MefH), 0.48 mM. Pretreatment of animals with MefH or LDH-Mef reduced carrageenan-, dextran sulfate- and PGE2-induced paw edema. MefH or LDH-Mef also decrease total leucocytes and neutrophil counts of the peritoneal cavity after inflammation induction with carrageenan. In the nociception model, oral pretreatment with LDH-Mef reduced mechanical hypernociception carrageenan-induced after 3–4 h and also the number of writhings induced by acetic acid. Conclusions This work shows the increase of the anti-inflammatory and antinociceptive potential of the drug confined into the LDH, as well as, its hemolytic effect.
Descrição: CUNHA, Vanessa R.R. et al. Delivery system for mefenamic acid based on the nanocarrier layered double hydroxide : physicochemical characterization and evaluation of anti-inflammatory and antinociceptive potential. Materials Science & Engineering. C, Biomimetic Materials, Sensors and Systems, Lausanne, v. 58, p. 629-638, jan., 2016.
URI: http://www.repositorio.ufc.br/handle/riufc/22033
ISSN: 0928-4931 On line
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