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Title in Portuguese: Tumor necrosis factor prevents Candida albicans biofilm formation
Author: Rocha, Francisco Airton Castro
Alves, Anelise Maria Costa Vasconcelos
Rocha, Marcos Fábio Gadelha
Cordeiro, Rossana de Aguiar Cordeiro
Brilhante, Raimunda Sâmia Nogueira
Pinto, Ana Carolina Matias Dinelly
Nunes, Rodolfo de Melo
Girão, Virgínia Cláudia Carneiro
Sidrim, José Julio Costa
Keywords: Candida albicans
Issue Date: Apr-2017
Publisher: Scientific Reports
Citation: ROCHA, F. A.C. et al. Tumor necrosis factor prevents Candida albicans biofilm formation. Scientific Reports, v. 7, p. 1-7, apr. 2017.
Abstract: Candida species are commensals but some develop biofilms in prosthetic materials and host surfaces that may represent up to 30% of deaths related to infections, particularly in immunosuppressed patients. Tumor necrosis factor (TNF) exhibits a plethora of functions in host defense mechanisms whereas excessive release of TNF in inflammation promotes tissue damage. Cytokines released in an inflammatory milieu may influence the development of microorganisms either by promoting their growth or displaying antimicrobial activity. In protozoa, TNF may affect growth by coupling through a lectin-like domain, distinct from TNF receptors. TNF was also shown to interact with bacteria via a mechanism that does not involve classical TNF receptors. Using an in vitro C. albicans biofilm model, we show that TNF dose-dependently prevents biofilm development that is blocked by incubating TNF with N , N ’-diacetylchitobiose, a major carbohydrate component of C. albicans cell wall. This finding represents a relevant and hitherto unknown mechanism that adds to the understanding of why TNF blockade is associated with opportunistic C. albicans infections.
metadata.dc.type: Artigo de Periódico
ISSN: 2045-2322
Appears in Collections:DMC - Artigos publicados em revistas científicas

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