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Title in Portuguese: Intoxication local anaesthetics : intravenous use of lipid emulsion as antidote
Author: Rodigues Neto, Edilson Martins
Marques, Lidia Audrey Rocha Valadas
Girão Junior, Francisco Josimar
Ponte, Emerson Dias
Campos, Márcia Oliveira Coelho
Ferreira, Maria Augusta Drago
Lobo, Patrícia Leal Dantas
Fonteles, Marta Maria França
Keywords: Anestésicos
Issue Date: 2017
Publisher: Journal of Chemical and Pharmaceutical Research
Citation: RODRIGUES NETO, E. M. et al. Intoxication local anaesthetics : intravenous use of lipid emulsion as antidote. Journal of Chemical and Pharmaceutical Research, v. 9, n. 3, p. 368-372, 2017.
Abstract: The local anesthetic technique when performed with a quality product results in the abolition of autonom ic and sensory motors functions . The c ardiotoxicity caused by local anesthetics is a hard condition to manage, given traditional therapies, which are quite limited. Thus, it is crucial to evaluate the clinical fea sibility of using Lipid Emulsion (LE) intravenously in the treatment of poisoning by local anesthetics, because this may be a viable therapeutic option as re scue procedure. Currently , in the hypothetical level that the LE acts by three distinct mechanisms of action: Formation of a "Lipid Trap," transport of fatty acids to the mitochondria of the cardiac muscle tissue and a positive inotropic effect in the myocardium. One can derive that its clinical utility in cardiovascular collapse is higher in the first moments of intoxication AL, before installation of the situation of hypoxia and/or metabolic acidosis. In this context the use of LE as therapy for acute intoxication AL appears as a safe and effective alternative, with a very low risk profile and with a g ood degree documented evidence of benefit. Thus, it is important for the surgical team's the knowledge of this therapy in the cardiotoxicity management caused by acute intoxication for AL.
ISSN: 0975 - 7384
Appears in Collections:DFAR - Artigos publicados em revistas científicas

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