Please use this identifier to cite or link to this item: http://www.repositorio.ufc.br/handle/riufc/24769
Title in Portuguese: Nonverbal behaviors are associated with increased vagal activity in major depressive disorder : implications for the polyvagal theory
Author: Fernandes, Raquel A.
Fiquer, Juliana T.
Gorenstein, Clarice
Razza, Lais Boralli
Fraguas Jr, Renério
Borrione, Lucas
Benseñor, Isabela M.
Lotufo, Paulo A.
Dantas, Eduardo Miranda
Carvalho, Andre F.
Brunoni, André R.
Keywords: Transtorno Depressivo Maior
Depressive Disorder, Major
Psiquiatria
Issue Date: Feb-2017
Publisher: Journal of Affective Disorders
Citation: FERNANDES, Raquel A. et al. Nonverbal behaviors are associated with increased vagal activity in major depressive disorder : Implications for the polyvagal theory. Journal of Affective Disorders, v. 209, p. 18-22, feb. 2017.
Abstract: Background Major depressive disorder (MDD) is associated with impairments in nonverbal behaviors (NVBs) and vagal activity. The polyvagal theory proposes that vagal activity regulates heart rate and NVBs by modulating a common anatomically and neurophysiologically discrete social engagement system. However, the association between these putative endophenotypes has not yet been explored. We hypothesize that in MDD, NVBs indicating positive affects and social interest and those indicating negative feelings and social disinterest could be associated with different patterns of vagal activity. Methods For this cross-sectional study we recruited 50 antidepressant-free participants with moderate-to-severe MDD. Vagal activity was indexed by heart rate variability (HRV) measures, and positive and negative nonverbal behaviors (NVBs) by a validated ethogram. Associations between NVBs and HRV were explored by bivariate analyses and multivariable models were adjusted by age, gender, depression severity, and self-reported positive and negative affects. Results HRV measures indicative of higher vagal activity were positively correlated with positive NVBs exhibited during the clinical interview. Conversely, NVBs related to negative affects, low energy and social disinterest were not associated with HRV. Limitations Absence of a control group. Conclusions The findings highlight that the examined depression endophenotypes (nonverbal behaviors and vagal activity) are related, shedding light on MDD pathophysiology in the context of the polyvagal theory.
URI: http://www.repositorio.ufc.br/handle/riufc/24769
metadata.dc.type: Artigo de Periódico
ISSN: 0165-0327
Appears in Collections:DMC - Artigos publicados em revistas científicas

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