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Title in Portuguese: Gut microbiota, bacterial translocation, and interactions with diet : pathophysiological links between major depressive disorder and non-communicable medical comorbidities
Author: Slyepchenko, Anastasiya
Maes, Michael
Jacka, Felice N.
Köhler, Cristiano A.
Barichello, Tatiana
McIntyre, Roger S.
Berk, Michael
Grande, Iria
Foster, Jane A.
Vieta, Eduard
Carvalho, André F.
Keywords: Obesidade
Síndrome de Fadiga Crônica
Fatigue Syndrome, Chronic
Issue Date: 2017
Publisher: Psychotherapy and psychosomatics
Citation: SLYEPCHENKO, Anastasiya et al. Gut microbiota, bacterial translocation, and Interactions with diet : pathophysiological links between major depressive disorder and non-communicable medical comorbidities. Psychotherapy and psychosomatics, Basel, v. 88, p. 31-46, 2017.
Abstract: Background: Persistent low-grade immune-inflammatory processes, oxidative and nitrosative stress (O&NS), and hy- pothalamic-pituitary-adrenal axis activation are integral to the pathophysiology of major depressive disorder (MDD). The microbiome, intestinal compositional changes, and re-sultant bacterial translocation add a new element to the bi- directional interactions of the gut-brain axis; new evidence implicates these pathways in the patho-aetiology of MDD. In addition, abnormalities in the gut-brain axis are associated with several chronic non-communicable disorders, which frequently co-occur in individuals with MDD, including but not limited to irritable bowel syndrome (IBS), chronic fatigue syndrome (CFS), obesity, and type 2 diabetes mellitus (T2DM). Methods: We searched the PubMed/MEDLINE data- base up until May 1, 2016 for studies which investigated in- testinal dysbiosis and bacterial translocation (the ‘leaky gut’) in the pathophysiology of MDD and co-occurring somatic
metadata.dc.type: Artigo de Periódico
ISSN: 0033-3190
Appears in Collections:DMC - Artigos publicados em revistas científicas

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