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Title in Portuguese: Lurasidone in the treatment of bipolar depression : systematic review of systematic reviews
Author: Fornaro, Michele
Berardis, Domenico de
Perna, Giampaolo
Solmi, Marco
Veronese, Nicola
Orsolini, Laura
Buonaguro, Elisabetta Filomena
Iasevoli, Felice
Köhler, Cristiano André
Carvalho, André Ferrer
Bartolomeis, Andrea de
Keywords: Depressão
Transtorno Bipolar
Bipolar Disorder
Issue Date: May-2017
Publisher: Biomed Research International
Citation: FORNARO, Michele et al. Lurasidone in the treatment of bipolar depression : systematic review of systematic reviews. Biomed Research International, v. 2017, p. 1-18, may, 2017.
Abstract: Introduction. A burgeoning number of systematic reviews considering lurasidone in the treatment of bipolar depression have occurred since its Food and Drug Administration extended approval in 2013. While a paucity of available quantitative evidence still precludes preliminary meta-analysis on the matter, the present quality assessment of systematic review of systematic reviews, nonetheless, aims at highlighting current essential information on the topic. Methods. Both published and unpublished systematic reviews about lurasidone mono- or adjunctive therapy in the treatment of bipolar depression were searched by two independent authors inquiring PubMed/Cochrane/Embase/Scopus from inception until October 2016. Results. Twelve included systematic reviews were of moderate-to-high quality and consistent in covering the handful of RCTs available to date, suggesting the promising efficacy, safety, and tolerability profile of lurasidone. Concordance on the drug profile seems to be corroborated by a steadily increasing number of convergent qualitative reports on the matter. Limitations. Publication, sponsorship, language, citation, and measurement biases. Conclusions. Despite being preliminary in nature, this overview stipulates the effectiveness of lurasidone in the acute treatment of Type I bipolar depression overall. As outlined by most of the reviewed evidence, recommendations for future research should include further controlled trials of extended duration.
metadata.dc.type: Artigo de Periódico
ISSN: 2314-6133
2314-6141 (Online)
Appears in Collections:DMC - Artigos publicados em revistas científicas

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