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Title in Portuguese: Shared metabolic and immune-in fl ammatory, oxidative and nitrosative stress pathways in the metabolic syndrome and mood disorders
Author: Melo, Luiz Gustavo Piccoli de
Nunes, Sandra Odebrecht Vargas
Anderson, George
Vargas, Heber Odebrecht
Barbosa, Décio Sabbattini
Galecki, Piotr
Carvalho, André F.
Maes, Michael
Keywords: Estresse Oxidativo
Oxidative stress
Bipolar disorders
Transtorno Bipolar
Issue Date: Aug-2017
Publisher: Progress in Neuropsychopharmacology & Biological Psychiatry
Citation: MELO, Luiz Gustavo Piccoli de et al. Shared metabolic and immune-in flammatory, oxidative and nitrosative stress pathways in the metabolic syndrome and mood disorders. Progress in Neuropsychopharmacology & Biological Psychiatry, v. 78, p. 34-50, aug. 2017.
Abstract: This review examines the shared immune-in fl ammatory, oxidative and nitrosative stress (IO & NS) and metabolic pathways underpinning metabolic syndrome (MetS), bipolar disorder (BD) and major depressive disorder (MDD). Shared pathways in both MetS and mood disorders are low grade in fl ammation, including increased levels of pro-in fl ammatory cytokines and acute phase proteins, increased lipid peroxidation with formation of malondialdehyde and oxidized low density lipoprotein cholesterol (LDL-c), hypernitrosylation, lowered levels of antioxidants, most importantly zinc and paraoxonase (PON1), increased bacterial translocation (leaky gut), increased atherogenic index of plasma and Castelli risk indices; and reduced levels of high-density lipoprotein (HDL-c) cholesterol. Insulin resistance is probably not a major factor associated with mood disorders. Given the high levels of IO & NS and metabolic dysregulation in BD and MDD and the high comorbidity with the atherogenic components of the MetS, mood disorders should be viewed as systemic neuro-IO & NS-metabolic disorders. The IO & NS-metabolic biomarkers may have prognostic value and may contribute to the development of novel treatments targeting neuro-immune, neuro-oxidative and neuro-nitrosative pathways.
metadata.dc.type: Artigo de Periódico
ISSN: 0278-5846
Appears in Collections:DMC - Artigos publicados em revistas científicas

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