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|Title in Portuguese:||The relationship between genetic risk variants with brain structure and function in bipolar disorder : a systematic review of genetic-neuroimaging studies|
|Author:||Pereira, Licia P.|
Köhler, Cristiano A.
Sousa, Rafael T. de
Freitas, Bárbara P. de
Miskowiak, Kamilla W.
Carvalho, André F.
Imagem por Ressonância Magnética
|Publisher:||Neuroscience and Biobehavioral Reviews|
|Citation:||PEREIRA, Licia P. et al. The relationship between genetic risk variants with brain structure and function in bipolar disorder : a systematic review of genetic-neuroimaging studies, v, 79, p. 87-109, aug. 2017.|
|Abstract:||Genetic-neuroimaging paradigms could provide insights regarding the pathophysiology of bipolar disorder (BD). Nevertheless, fi ndings have been inconsistent across studies. A systematic review of gene-imaging studies involving individuals with BD was conducted across electronic major databases from inception until January 9th, 2017. Forty-four studies met eligibility criteria (N = 2122 BD participants). Twenty-six gene variants were investigated across candidate gene studies and 4 studies used a genome-wide association approach. Replicated evidence (i.e. in > 2 studies) suggests that individuals with BD carrying the BDNF Val66Met risk allele could have reduced hippocampal volumes compared to non-carriers. This review underscores the potential of gene- neuroimaging paradigms to provide mechanistic insights for BD. However, this systematic review found a single replicated fi nding. Suggestions to improve the reproducibility of this emerging fi eld are provided, including the adoption of a trans-diagnostic approach.|
|metadata.dc.type:||Artigo de Periódico|
|Appears in Collections:||DMC - Artigos publicados em revistas científicas|
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