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Title in Portuguese: Thyroid autoimmunity in bipolar disorder : a systematic review
Author: Barbuti, Margherita
Carvalho, André F.
Köhlerc, Cristiano A.
Murru, Andrea
Verdolini, Norma Verdolini
Guiso, Giovanni
Samalin, Ludovic
Maes, Michael
Stubbs, Brendon
Perugi, Giulio
Vieta, Eduard
Pacchiarotti, Isabella
Keywords: Bipolar disorder
Issue Date: 2017
Publisher: Journal of Affective Disorders
Citation: BARBUTI, M. et al. Thyroid autoimmunity in bipolar disorder : a systematic review, Journal of Affective disorders, v. 221, p. 97-106, 2017.
Abstract in Portuguese: Background: Accumulating evidence points to the pathophysiological relevance between immune dysfunction and mood disorders. High rates of thyroid dysfunction have been found in patients with bipolar disorder (BD), compared to the general population. A systematic review of the relationship between BD and thyroid autoimmunity was performed. Methods: Pubmed, EMBASE and PsycINFO databases were searched up till January 28th, 2017. This review has been conducted according to the PRISMA statements. Observational studies clearly reporting data among BD patients and the frequency of autoimmune thyroid pathologies were included. Results: 11 original studies met inclusion criteria out of 340 titles first returned from the global search. There is evidence of increased prevalence of circulating thyroid autoantibodies in depressed and mixed BD patients, while there is no evidence showing a positive relationship between BD and specific autoimmune thyroid diseases. There is a controversy about the influence of lithium exposure on circulating thyroid autoantibodies, even if most of studies seem not to support this association. A study conducted on bipolar twins suggests that autoimmune thyroiditis is related to the genetic vulnerability to develop BD rather than to the disease process itself. Females are more likely to develop thyroid autoimmunity. Limitations: The samples, study design and outcomes were heterogeneous. Conclusion: Thyroid autoimmunity has been suggested to be an independent risk factor for bipolar disorder with no clear association with lithium exposure and it might serve as an endophenotype for BD.
metadata.dc.type: Artigo de Periódico
ISSN: 0165-0327
Appears in Collections:DMC - Artigos publicados em revistas científicas

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