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Title in Portuguese: Kidney involvement in malaria : an update
Author: Silva Junior, Geraldo Bezerra da
Pinto, José Reginaldo
Barros, Elvino José Guardão
Farias, Geysa Maria Nogueira
Daher, Elizabeth De Francesco
Keywords: Malária
Issue Date: Aug-2017
Publisher: Revista do Instituto de Medicina Tropical de São Paulo
Citation: SILVA JUNIOR, Geraldo Bezerra de et al. Kidney involvement in malaria: an update. Revista do Instituto de Medicina Tropical de São Paulo, São Paulo, v. 59, p. 1-6, ago. 2017.
Abstract: Malaria is an infectious disease of great importance for Public Health, as it is the most prevalent endemic disease in the world, affecting millions of people living in tropical areas of the globe. Kidney involvement is relatively frequent in infections by P. falciparum and P. malariae, but has also been described in the infection by P. vivax. Kidney complications in malaria mainly occur due to hemodynamic dysfunction and immune response. Liver complications leading to hepatomegaly, jaundice and hepatic dysfunction can also contribute to the occurrence of acute kidney injury. Histologic studies in malaria also evidence glomerulonephritis, acute tubular necrosis and acute interstitial nephritis. It is also possible to find chronic kidney disease associated with malaria, mainly in those patients suffering from repeated episodes of infection. Plasmodium antigens have already been detected in the glomeruli, suggesting a direct effect of the parasite in the kidney, which can trigger an inflammatory process leading to different types of glomerulonephritis. Clinical manifestations of kidney involvement in malaria include proteinuria, microalbuminuria and urinary casts, reported in 20 to 50% of cases. Nephrotic syndrome has also been described in the infection by P. falciparum, but it is rare. This paper highlights the main aspects of kidney involvement in malaria and important findings of the most recent research addressing this issue.
metadata.dc.type: Artigo de Periódico
ISSN: On-line version 1678-9946
Appears in Collections:DMC - Artigos publicados em revistas científicas

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