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|Title in Portuguese:||Violacein antimicrobial activity on Staphylococcus epidermidis and synergistic effect on commercially available antibiotics|
Batista, A. H. de Morais
Medeiros, S. C. de
Rodrigues, M. L.
Nogueira, N. A. P.
|Publisher:||Journal of applied microbiology|
|Citation:||DODOU, H. V. et al. Violacein antimicrobial activity on Staphylococcus epidermidis and synergistic effect on commercially available antibiotics. Journal of applied microbiology, Oxford, v. 123, p. 853-860, 2017.|
|Abstract:||Aims: The study aimed to assess whether violacein has antimicrobial activity on Staphylococcus epidermidis and synergistically modulates the action of commercially available antimicrobial drugs. Methods and Results: Violacein showed excellent antimicrobial activity on biofilm-forming and nonbiofilm-forming S. epidermidis strains (ATCC 35984) (ATCC 12228), with bacteriostatic (MIC = 20 lg ml 1 and 10 lg ml 1 respectively) and bactericidal effects (MBC = 20 lg ml 1 for both strains), observed in short periods of exposure. The violacein bactericidal concentration led to S. epidermidis death after 2–3 h of exposure. Additionally, violacein synergistically modulated the activity of different antimicrobial classes on S. epidermidis ATCC 12228 (81 8%; n = 9) and on S. epidermidis ATCC 35984 (54 5%; n = 6), reducing the MIC of these antibiotics by up to 16-fold. Conclusion: Violacein shows excellent antimicrobial activity on S. epidermidis strains. Significance and Impact of the Study: Violacein shows the potential for the development of a new drug for the treatment of infections caused by S. epidermidis.|
|Appears in Collections:||DFAR - Artigos publicados em revistas científicas|
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