Please use this identifier to cite or link to this item: http://www.repositorio.ufc.br/handle/riufc/26599
Title in Portuguese: Interleukin-18 (IL-18) is equally expressed in inflammatory breast cancer and noninflammatory locally advanced breast cancer : a possible association with chemotherapy response
Author: Aguiar, Marco Antônio Nasser
Wanderley, Carlos Wagner S.
Nobre, Lívia Maria Soares
Alencar, Mateus Rolim Mendes Alencar
Saldanha, Maria do Perpétuo Socorro
Souza, Alceu Machado
Wong, Deysi Viviana Tenazoa
Barros, Paulo Goberlânio
Almeida, Paulo Roberto Carvalho
Lima-Júnior, Roberto Cesar Pereira
Ribeiro, Ronaldo Albuquerque
Keywords: Neoplasias da Mama
Interleucina-18
Breast Neoplasms
Issue Date: 2017
Publisher: Asia-Pacific Journal of Clinical Oncology
Citation: AGUIAR, M. A. N. et al. Interleukin-18 (IL-18) is equally expressed in inflammatory breast cancer and noninflammatory locally advanced breast cancer : a possible association with chemotherapy response. Asia-Pacific Journal of Clinical Oncology, p. 1-7, 2017.
Abstract: Aim: Inflammatory breast cancer (IBC) is the most aggressive form of locally advanced breast can- cer. The signs of inflammation such as hyperemia and hyperthermia might suggest the possible participation of inflammatory mediators. This study investigates stromal and tumor expression of nuclear factor-kappa B (NF-B) and interleukin-18 (IL-18) in samples obtained from IBC and noninflammatory locally advanced breast cancer (LABC) and the influence of these markers on patients’ prognosis. Methods: Demographic data, tumor molecular characteristics and overall survival in both groups were also assessed. Furthermore, in this study, we evaluated the expression of IL-18 and p50 nuclear fraction of NF-B by immunohistochemistry in specimens from IBC and LABC (T4b). Results: We observed that 24.6% of women were diagnosed with IBC up to age 40. In addition, the patients with IBC showed a lower overall survival when compared to LABC. In regard to molecu- lar markers, ER + , C-erbB2 − or triple negative IBC patients showed a significantly reduced over- all survival. In addition, a higher IL-18 immunostaining in stroma of IBC and LABC was observed in comparison with tumor cells, but stromal immunoexpression was similar between IBC and LABC. Besides, IL-18 positivity seemed be related with a better clinical response to neoadjuvant chemotherapy. However, NF-B expression was identical in both groups. Conclusion: The IL-18 is present in tumor stroma of IBC and LABC and seems to be associated with the complete response to neoadjuvant chemotherapy.
URI: http://www.repositorio.ufc.br/handle/riufc/26599
ISSN: 1743-7555
1743-7563
Appears in Collections:DFAR - Artigos publicados em revistas científicas

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