Please use this identifier to cite or link to this item: http://www.repositorio.ufc.br/handle/riufc/26600
Title in Portuguese: Anti-inflammatory effect of the monoterpene myrtenol is dependent on the direct modulation of neutrophil migration and oxidative stress
Author: Gomes, Bruno S.
S. Neto, Benedito P.
Lopes, Everton M.
Cunha, Francisco V. M.
Araújo, Alyne R.
Wanderley, Carlos W. S.
Wong, Deysi V. T.
L. Júnior, Roberto César P.
Ribeiro, Ronaldo A.
Sousa, Damião P.
Medeiros, Jand Venes R.
Oliveira, Rita C.M.
Oliveira, Francisco A.
Keywords: Estresse Oxidativo
Neutrófilos
Neutrophils
Oxidative Stress
Issue Date: Aug-2017
Publisher: Chemico-Biological Interactions
Citation: GOMES, B. S. et al. Anti-inflammatory effect of the monoterpene myrtenol is dependent on the direct modulation of neutrophil migration and oxidative stress. Chemico-Biological Interactions, v. 273, p.73-81, aug. 2017.
Abstract: Myrtenol is a bicyclic monoterpene with anti-in fl ammatory properties. However, the mechanisms involved are partially unknown. Here, we investigated the effect of myrtenol during experimental chronic arthritis and the possible modulating activity of oxidative stress and neutrophil migration. Complete Freund's Adjuvant (CFA)-sensitized rats were treated with vehicle (1 mL/kg, po), myrtenol (12.5, 25 or 50 mg/kg, po), indomethacin (10 mg/kg, po) or dexamethasone (0.4 mg/kg) followed by intra-articular injection of CFA (0.5 mg/mL, 50 m L per joint). Then, paw edema and articular incapaci- tation (paw elevation time) were evaluated for 14 days. On the last day, a blood concentration superoxide dismutase (SOD) and nitrite was determined. In another experimental setting, human neutrophils were incubated with vehicle (sterile saline, 1 mL) or myrtenol (10 e 100 ng/mL) and the in vitro chemotaxis to N-formylmethionine-leucyl-phenylalanine (fMLP) (10 7 M/well) was evaluated. In addition, antiin- fl ammatory effect of myrtenol was investigated in carrageenan-induced peritonitis. We found that CFA induced a prominent paw swelling and incapacitation of the joint, which were signi fi cantly prevented by myrtenol ( P < 0.05). In addition, blood accumulation nitrite was attenuated by myrtenol when compared with vehicle-treated CFA group ( P < 0.05). Furthermore, plasma levels of SOD were signi fi cantly increased by myrtenol versus vehicle-treated CFA group ( P < 0.05). Moreover, fMLP-triggered neutrophil chemotaxis and carrageenan-induced peritonitis were markedly prevented by myrtenol ( P < 0.05). Therefore, myrtenol showed anti-in fl ammatory and antinociceptive effects on experimental chronic arthritis, which seems to be related to the direct modulation of neutrophil migration and antioxidant activity
URI: http://www.repositorio.ufc.br/handle/riufc/26600
ISSN: 0009-2797
1872-7786
Appears in Collections:DFAR - Artigos publicados em revistas científicas

Files in This Item:
File Description SizeFormat 
2017_art_bsgomes.pdf1,52 MBAdobe PDFView/Open


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.