Please use this identifier to cite or link to this item: http://www.repositorio.ufc.br/handle/riufc/30492
Title in Portuguese: Heme oxygenase-1/biliverdin/carbon monoxide pathway downregulates hypernociception in rats by a mechanism dependent on cGMP/ATP-sensitive K+ channels
Author: Chaves, Hellíada Vasconcelos
Val, Danielle Rocha do
Ribeiro, Kátia Alves
Lemos, Jonas Cavalcante
Souza, Ricardo Basto
Gomes, Francisco Isaac Fernandes
Cunha, Rodrigo Maranguape Silva da
Pinto, Vicente de Paulo Teixeira
Cristino Filho, Gerardo
Souza, Marcellus Henrique Loiola Ponte de
Bezerra, Mirna Marques
Brito, Gerly Anne de Castro
Keywords: Articulação Temporomandibular
Temporomandibular Joint
Issue Date: Jan-2018
Publisher: Inflammation Research
Citation: CHAVES, H. V. et al. Heme oxygenase-1/biliverdin/carbon monoxide pathway downregulates hypernociception in rats by a mechanism dependent on cGMP/ATP-sensitive K+ channels. Inflammation Research, Basel, p. 1-16, jan. 2018.
Abstract: Objective and design To investigate the role of heme oxygenase-1 (HO-1), carbon monoxide (CO), and biliverdin (BVD) in the zymosan-induced TMJ arthritis in rats. Materials and Methods Mechanical threshold was assessed before and 4 h after TMJ arthritis induction in rats. Cell influx, myeloperoxidase activity, and histological changes were measured in the TMJ lavages and tissues. Trigeminal ganglion and periarticular tissues were used for HO-1, TNF-α, and IL-1β mRNA time course expression and immunohistochemical analyses. Hemin (0.1, 0.3, or 1 mg kg−1), DMDC (0.025, 0.25, or 2.5 µmol kg−1), biliverdin (1, 3, or 10 mg kg−1), or ZnPP-IX (1, 3 or 9 mg kg−1) were injected (s.c.) 60 min before zymosan. ODQ (12.5 µmol kg−1; s.c.) or glibenclamide (10 mg kg−1; i.p.) was administered 1 h and 30 min prior to DMDC (2.5 µmol kg−1; s.c), respectively. Results Hemin (1 mg kg−1), DMDC (2.5 µmol kg−1), and BVD (10 mg kg−1) reduced hypernociception and leukocyte migration, which ZnPP (3 mg kg−1) enhanced. The effects of DMDC were counteracted by ODQ and glibenclamide. The HO-1, TNF-α, and IL-1β mRNA expression and immunolabelling increased. Conclusions HO-1/BVD/CO pathway activation provides anti-nociceptive and anti-inflammatory effects on the zymosan-induced TMJ hypernociception in rats.
Description: CHAVES, Hellíada Vasconcelos
URI: http://www.repositorio.ufc.br/handle/riufc/30492
ISSN: 1023-3830 (Print)
1420-908X (Online)
Appears in Collections:DMC - Artigos publicados em revistas científicas

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