Please use this identifier to cite or link to this item: http://www.repositorio.ufc.br/handle/riufc/32419
Title in Portuguese: The endoplasmic reticulum stress response in neuroprogressive diseases: emerging pathophysiological role and translational implications
Author: Morris, Gerwyn
Puri, Basant K.
Walder, Ken
Berk, Michael
Stubbs, Brendon
Maes, Michael
Carvalho, André F.
Keywords: Transtornos do Humor
Mood Disorders
Endoplasmic Reticulum Stress
Estresse do Retículo Endoplasmático
Issue Date: Mar-2018
Publisher: Molecular Neurobiology
Citation: MORRIS, G. et al. The endoplasmic reticulum stress response in neuroprogressive diseases: emerging pathophysiological role and translational implications Molecular Neurobiology, New York, p. 1–23, mar. 2018.
Abstract: The endoplasmic reticulum (ER) is the main cellular organelle involved in protein synthesis, assembly and secretion. Accumulating evidence shows that across several neurodegenerative and neuroprogressive diseases, ER stress ensues, which is accompanied by over-activation of the unfolded protein response (UPR). Although the UPR could initially serve adaptive purposes in conditions associated with higher cellular demands and after exposure to a range of pathophysiological insults, over time the UPR may become detrimental, thus contributing to neuroprogression. Herein, we propose that immune-inflammatory, neuro-oxidative, neuro-nitrosative, as well as mitochondrial pathways may reciprocally interact with aberrations in UPR pathways. Furthermore, ER stress may contribute to a deregulation in calcium homoeostasis. The common denominator of these pathways is a decrease in neuronal resilience, synaptic dysfunction and even cell death. This review also discusses how mechanisms related to ER stress could be explored as a source for novel therapeutic targets for neurodegenerative and neuroprogressive diseases. The design of randomised controlled trials testing compounds that target aberrant UPR-related pathways within the emerging framework of precision psychiatry is warranted.
URI: http://www.repositorio.ufc.br/handle/riufc/32419
metadata.dc.type: Artigo de Periódico
ISSN: 0893-7648
1559-1182 (Online)
Appears in Collections:DSC - Artigos publicados em revista científica

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