Please use this identifier to cite or link to this item: http://www.repositorio.ufc.br/handle/riufc/34363
Title in Portuguese: The medicinal species Myracrodruon urundeuva Fr. All. presents antidiabetic and hypolipidemic properties, probably related to its antioxidant and anti-inflammatory actions
Author: Moreira, Alisson Cordeiro
Moreira, Ítalo Cordeiro
Alves, Viviane de Jesus
Carvalho, José Bégue Moreira
Lopes, Maria Janice Pereira
Aquino, Pedro Everson Alexandre de
Leal, Luzia Kalyne Almeida Moreira
Araújo, Emmanuel Vinicius Oliveira
Aquino, Nayara Coriolano de
Bezerra, Antônio Marcos Esmeraldo
Evangelista, Janaína Serra Azul Monteiro
Silveira, Edilberto Rocha
Viana, Glauce Socorro de Barros
Keywords: Hipolipemiantes
Hypolipidemic Agents
Hipoglicemiantes
Hypoglycemic Agents
Issue Date: Mar-2018
Publisher: Global Journal of Medicinal Plants Research
Citation: MOREIRA, A. C. et al. The medicinal species Myracrodruon urundeuva Fr. All. presents antidiabetic and hypolipidemic properties, probably related to its antioxidant and anti-inflammatory actions. Global Journal of Medicinal Plants Research, v. 4, n. 1, p. 342-351, mar., 2018.
Abstract: The Type 2 diabetes (T2D) is a global epidemics and considered as an inflammation related disease. Myracrodruon urundeuva (Anacardiaceae) is used in Northeast Brazil, because of its anti-inflammatory properties. The species is known to present tannins and chalcones among its active compounds. The objectives of the work were to investigate the antidiabetic and hypolipidemic activities of the stem bark decoction (MUSB) from a cultivated specimen of M. urundeuva, in the alloxan-induced diabetes model. For that, male Wistar rats were divided into normal controls, untreated and treated (MUSB, 50 and 100 mg/kg, 7 days) diabetic groups. Afterwards, the animals were subjected to biochemical measurements (glycemia, cholesterol, triglycerides and ALT and AST liver transaminases) before (48 h, post-alloxan) and after treatments, then euthanized for histopathological studies. The data were analyzed by ANOVA and Tukey’s test and considered significant for p<0.05. We observed significant decreases in glycemia, cholesterol and triglycerides values. ALT and AST values were within normal ranges. The histopathological examination revealed changes of somehow less intensity in treated diabetic, relatively to diabetic animals without treatment. An interesting finding was the beta cell proliferation observed in diabetic pancreas after MUSB treatments. The antidiabetic and hypolipidemic effects are possibly related to the anti-inflammatory and antioxidant actions of MUSB. The regulation of beta cell mass, as a strategic target for T2D treatment, should estimulate translational studies dealing with the effects of M. urundeuva on beta cell proliferation.
URI: http://www.repositorio.ufc.br/handle/riufc/34363
metadata.dc.type: Artigo
Appears in Collections:PPGF - Artigos publicados em revistas científica

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