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Title in Portuguese: Cellular differentiation, bioactive and mechanicalproperties of experimental light-curing pulpprotection materials
Author: Sauro, Salvatore
Babbar, Ashvin
Gharibi, Borzo
Feitosa, Victor Pinheiro
Carvalho, Ricardo Marins
Rodrigues, Lidiany Karla Azevedo
Banerjee, Avijit
Watson, Timothy
Keywords: Zinco
Teste de Materiais
Materials Testing
Issue Date: Jun-2018
Publisher: Dental Materials
Citation: SAURO, S. et al. Cellular differentiation, bioactive and mechanical properties of experimental light-curing pulp protection materials. Dental Materials, Washington, v. 34, n. 6, p. 868-878, jun. 2018.
Abstract: Objective. Materials for pulp protection should have therapeutic properties in order to stim-ulate remineralization and pulp reparative processes. The aim of this study was to evaluatethe mechanical properties, biocompatibility, cell differentiation and bioactivity of experi-mental light-curable resin-based materials containing bioactive micro-fillers.Methods. Four calcium-phosphosilicate micro-fillers were prepared and incorporated into aresin blend: 1) Bioglass 45S5 (BAG); 2) zinc-doped bioglass (BAG-Zn); 3) TCP-modified cal-cium silicate ( -CS); 4) zinc-doped -CS ( -CS-Zn). These experimental resins were testedfor flexural strength (FS) and fracture toughness (FT) after 24 h and 30-day storage in sim-ulated body fluid (SBF). Cytotoxicity was evaluated using MTT assay, while bioactivity wasevaluated using mineralization and gene expression assays (Runx-2 & ALP).Results. The lowest FS and FT at 24 h was attained with -CS resin, while all the other testedmaterials exhibited a decrease in FS after prolonged storage in SBF. -CS-Zn maintained astable FT after 30-day SBF aging. Incorporation of bioactive micro-fillers had no negativeeffect on the biocompatibility of the experimental materials tested in this study. The inclu-sion of zinc-doped fillers significantly increased the cellular remineralization potential andexpression of the osteogenic genes Runx2 and ALP (p < 0.05).
metadata.dc.type: Artigo de Periódico
ISSN: 0109-5641
Appears in Collections:DCOD - Artigos publicados em revistas científicas

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