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Title in Portuguese: Platelet count response to Helicobacter pylori eradication for idiopathic thrombocytopenic purpura in northeastern Brazil
Author: Barbosa, Alzira Maria de Castro
Ribeiro, Rosangela Albuquerque
Silva, Cícero Ígor Simões Moura
Cruz, Francisco Will Saraiva
Azevedo, Orleancio Gomes Ripardo de
Pitombeira, Maria Helena da Silva
Braga, Lucia Libanez Campelo
Keywords: Helicobacter pylori
Púrpura Trombocitopênica Idiopática
Purpura, Thrombocytopenic, Idiopathic
Issue Date: Jan-2018
Publisher: Revista Brasileira de Hematologia e Hemoterapia
Citation: BARBOSA, A. M. C. et al. Platelet count response to Helicobacter pylori eradication for idiopathic thrombocytopenic purpura in northeastern Brazil. Revista Brasileira de Hematologia e Hemoterapia, São Paulo, v. 40, n. 1, p. 12-17, jan./mar. 2018.
Abstract: Background: Several studies have demonstrated that platelet counts in Helicobacter pyloripositive patients with chronic idiopathic thrombocytopenic purpura improved significantly after successful eradication of the infection. However, depending of the geographical region of the study the results have been highly divergent. Objective: The purpose of this studywas to evaluate the effect of H. pylori eradication therapy on platelet count in a cohort of chronic idiopathic thrombocytopenic purpura patients from northeastern Brazil. Method: H. pylori status was determined in 28 chronic idiopathic thrombocytopenic purpura patients using the rapid urease test and histology. H. pylori-positive patients received standard triple therapy for one week. The effect of the eradication therapy was evaluated using the 13C-urea breath test two to three months after treatment. Results: The prevalence of H. pylori infection was similar to that found in the general population. Twenty-two patients (78.5%) were H. pylori-positive. Fifteen were treated, 13 (86%) of whom successfully. At six months, 4/13 (30%) displayed increased platelet counts, which remained throughout follow-up (12 months). Platelet response was not associated to mean baseline platelet count, duration of chronic idiopathic thrombocytopenic purpura, gender, age, previous use of medication, or splenectomy.
metadata.dc.type: Artigo de Periódico
ISSN: 1806-0870 (Online)
Appears in Collections:DMC - Artigos publicados em revistas científicas

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