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Title in Portuguese: Eugenol as a promising molecule for the treatment of dermatitis: antioxidant and anti-inflammatory activities and its nanoformulation
Author: Lopes, Amanda de Araújo
Fonseca, Francisco Noé da
Rocha, Talita Magalhães
Freitas, Lyara Barbosa de
Araújo, Emmanuel Vinicius Oliveira
Wong, Deysi Viviana Tenazoa
Lima Júnior, Roberto César Pereira
Leal, Luzia Kalyne Almeida Moreira
Keywords: Dermatite
Oils, Volatile
Óleos Voláteis
Issue Date: Dec-2018
Publisher: Oxidative Medicine and Cellular Longevity
Citation: LOPES, Amanda de Araújo et al. Eugenol as a promising molecule for the treatment of dermatitis: antioxidant and anti-inflammatory activities and its nanoformulation. Oxidative Medicine and Cellular Longevity, v. 2018, p. 1-14, dec. 2018.
Abstract: Contact dermatitis produces an inflammatory reaction primarily via stimulation of keratinocytes and cells of the immune system, which promote the release of cytokines, reactive oxygen species (ROS), and other chemical mediators. Eugenol (EUG, phenylpropanoid of essential oils) has attracted attention due to its anti-inflammatory properties, as well as antioxidant effect. On the other hand, it is volatile and insoluble and is a skin irritant. In this case, nanostructured systems have been successfully employed as a drug carrier for skin diseases since they improve both biological and pharmaceutical properties of active compounds. The cytotoxic, antioxidant, and anti-inflammatory effects of EUG were assessed in human neutrophils and keratinocytes. Additionally, polymeric nanocarries (NCEUG) were prepared to improve the chemical and irritant characteristics of EUG. EUG presented apparent safety and antioxidant and anti-inflammatory effects on human neutrophils, but presented cytotoxic effects on keratinocytes. However, the nanocapsules were able to reduce its cytotoxicity. An in vivo experiment of irritant contact dermatitis (ICD) in mice induced by TPA showed that NCEUG reduced significantly the ear edema in mice when compared to the EUG solution, as well as the leukocyte infiltration and IL-6 level, possibly due to better skin permeation and irritancy blockage. These findings suggest that EUG is a promising bioactive molecule, and its nanoencapsulation seems to be an interesting approach for the treatment of ICD.
metadata.dc.type: Artigo
ISSN: 1942-0900
Appears in Collections:PPGF - Artigos publicados em revistas científica

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