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Title in Portuguese: Etiology and severity of diarrheal diseases in infants at the semiarid region of Brazil: a case-control study
Author: Lima, Aldo A. M.
Oliveira, Domingos B.
JosianeS.Quetz, Josiane S.
Havt, Alexandre
Prata, Mara M. G.
Lima, Ila F. N.
Soares, Alberto M.
Q. Filho, José
Lima, Noe ́liaL. Lima
Medeiros, Pedro H. Q. S.
Santos, Ana K. S.
Veras, Herlice N.
Gondim, Rafhaella N. D. G.
Pankov, Rafaela C.
Bona, Mariana D.
Rodrigues, Francisco A. P.
Moreira, Renato A.
Moreira, Ana C. O. M.
Bertolini, Marcelo
Bertolini, Luciana R.
Freitas, Vicente J. F.
Houpt, Eric R.
Guerran, Richard L.
Keywords: Diarreia
Issue Date: Feb-2019
Publisher: PLoS Neglected Tropical Diseases
Citation: LIMA, Aldo A. M. et al. Etiology and severity of diarrheal diseases in infants at the semiarid region of Brazil: a case-control study. PLoS Negl Trop Dis, v. 13, n. 2, e0007154, feb. 2019.
Abstract: Background Diarrheal diseases are an important cause of morbidity and mortality among children in developing countries. We aimed to study the etiology and severity of diarrhea in children living in the low-income semiarid region of Brazil. Methodology This is a cross-sectional, age-matched case-control study of diarrhea in children aged 2–36 months from six cities in Brazil’s semiarid region. Clinical, epidemiological, and anthropometric data were matched with fecal samples collected for the identification of enteropathogens. Results We enrolled 1,200 children, 596 cases and 604 controls. By univariate analysis, eight enteropathogens were associated with diarrhea: Norovirus GII (OR 5.08, 95% CI 2.10, 12.30), Adenovirus (OR 3.79, 95% CI 1.41, 10.23), typical enteropathogenic Escherichia coli (tEPEC), (OR 3.28, 95% CI 1.39, 7.73), enterotoxigenic E. coli (ETEC LT and ST producing toxins), (OR 2.58, 95% CI 0.99, 6.69), rotavirus (OR 1.91, 95% CI 1.20, 3.02), shiga toxinproducing E. coli (STEC; OR 1.77, 95% CI 1.16, 2.69), enteroaggregative E. coli (EAEC), (OR 1.45, 95% CI 1.16, 1.83) and Giardia spp. (OR 1.39, 95% CI 1.05, 1.84). By logistic regression of all enteropathogens, the best predictors of diarrhea were norovirus, adenovirus, rotavirus, STEC, Giardia spp. and EAEC. A high diarrhea severity score was associated with EAEC. Conclusions Six enteropathogens: Norovirus, Adenovirus, Rotavirus, STEC, Giardia spp., and EAEC were associated with diarrhea in children from Brazil’s semiarid region. EAEC was associated with increased diarrhea severity.
metadata.dc.type: Artigo
ISSN: 1935-2727
1935-2735 (On line)
Appears in Collections:PPGF - Artigos publicados em revistas científica

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