Use este identificador para citar ou linkar para este item: http://repositorio.ufc.br/handle/riufc/46425
Tipo: Artigo de Periódico
Título: Mixed infection by Histoplasma capsulatum isolates with different mating types in Brazilian AIDS-patients
Autor(es): Damasceno, Lisandra Serra
Vite-Garín, Tania
Ramírez, José Antonio
Rodríguez-Arellanes, Gabriela
Almeida, Marcos Abreu de
Muniz, Mauro de Medeiros
Mesquita, Jacó Ricarte Lima de
Leitão, Terezinha do Menino Jesus Silva
Taylor, Maria Lucia
Zancopé-Oliveira, Rosely Maria
Palavras-chave: Coinfecção;Coinfection;Histoplasma;Histoplasmose;Histoplasmosis;HIV
Data do documento: Fev-2019
Instituição/Editor/Publicador: Revista do Instituto de Medicina Tropical de São Paulo
Citação: DAMASCENO, Lisandra Serra et al. Mixed infection by Histoplasma capsulatum isolates with different mating types in Brazilian AIDS-patients. Rev. Inst. Med. trop., São Paulo, v. 61, p. 1-10, feb. 2019.
Abstract: Mixed infection by Histoplasma capsulatum isolates with different mating types, in AIDS-patients are described in this study. Morphological, mating type-specific PCR assay and multilocus sequencing type analysis of H. capsulatum isolates recovered from two Brazilian AIDS-patients were performed. Five H. capsulatum isolates were recovered at different times from the two patients. Three isolates were obtained from bone marrow (day 1 – CE0411) and buffy coat cultures (day 1 – CE0311; day 2 – CE0511) of patient 1, and two isolates were isolated from buffy coat cultures (day 3 – CE2813; day 12 – CE2513) of patient 2. The mycelial colonies depicted different textures and pigmentation features. Dimorphic conversion to the yeast-phase in ML-Gema medium was achieved in all isolates. MAT1-1 idiomorph was identified in CE0311, CE0411 and CE2813 isolates; MAT1-2 idiomorph was found in CE0511 and CE2513 isolates. These H. capsulatum isolates were grouped within LAm A clade, highlighting that CE0311 and CE0411 isolates formed a subgroup supported by a high bootstrap value. The CE0511, CE2513, and CE2813 isolates clustered together with a Brazilian H151 isolate. This research reports mixed infections caused by H. capsulatum isolates with different mating types in Brazilian AIDS-patients for the first time in the literature.
URI: http://www.repositorio.ufc.br/handle/riufc/46425
ISSN: On-line 1678-9946
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