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Title in Portuguese: Zika virus infection and microcephaly: a case-control study in Brazil
Author: Rocha, Sabrina Gabriele Maia Oliveira
Correia, Luciano Lima
Cunha, Antônio José Lêdo Alves da
Rocha, Hermano Alexandre Lima
Madeiro, Álvaro Jorge Madeiro
Campos, Jocileide Sales
Bandeira, Tereza de Jesus Pinheiro Gomes
Nascimento, Lucas Silveira do
Silva, Anamaria Cavalcante e
Keywords: Infecção por Zika virus
Zika Virus Infection
Issue Date: Aug-2019
Publisher: Annals of Global Health
Citation: ROCHA, Sabrina Gabriele Maia Oliveira et al. Zika virus infection and microcephaly: a case-control study in Brazil. Annals of Global Health, v.85, n. 1, p. 1–11, aug. 2019.
Abstract: Background: Brazil presented an alarming number of newborns with microcephaly in the years 2015 and 2016. The investigation of the cases raised the suspicion of the association of these cases with maternal infections by the zika virus. Also, in 2015, there was an epidemic of zika virus infection in Brazil, reinforcing this hypothesis. Objective: The objective of this study was to identify factors associated with the diagnosis of microcephaly in newborns, including zika virus infection. Methods: We conducted a case-control study. The cases were defined as children who received clinical and imaging diagnosis of microcephaly, born after October 2015 in Ceará, Brazil, which recorded the highest number of microcephaly cases in Brazil during the outbreak. The cases were identified in medical records of public and private maternity hospitals and in child development stimulation clinics tracked until June 2017. Epidemiological, clinical, and socioeconomic variables were collected, visiting their homes and confirming data from their medical records. Controls were children without microcephaly identified in the vicinity of the residence of each case. Logistic regression models were used to control confounding. Findings: We evaluated 58 cases and 116 controls. The odds of having a baby with microcephaly was 14 times higher among mothers who had zika virus infection (p < 0.001), after multivariate analysis. Arboviruses infections symptoms, as fever (p = 0.220), skin change (p < 0.001), and joint pain (p = 0.002) also demonstrated an association with microcephaly. Conclusions: Maternal infection zika virus was associated with a diagnosis of microcephaly. Our study contributes to the investigation of the epidemiological factors associated with the diagnosis of microcephaly.
metadata.dc.type: Artigo de Periódico
ISSN: 2214-9996
Appears in Collections:MPSF - Artigos publicados em revistas científicas

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