Please use this identifier to cite or link to this item: http://www.repositorio.ufc.br/handle/riufc/49902
Title in Portuguese: Essential oils from croton species: chemical composition, in vitro and in silico Antileishmanial evaluation, antioxidant and cytotoxicity activities
Author: Morais, Selene M.
Cossolosso, Danyelle S.
Silva, Antonio A. S.
Moraes Filho, Manoel O. de
Teixeira, Maria J.
Campello, Claudio C.
Bonilla, Oriel H.
Paula Júnior, Valdir F. de
Vila-Nova, Nadja S.
Keywords: Euphorbiaceae
Leishmania
Óleos Voláteis
Oils, Volatile
Óleo de Cróton
Croton Oil
Issue Date: 2019
Publisher: Journal of the Brazilian Chemical Society
Citation: MORAIS, Selene M. et al. Essential oils from croton species: chemical composition, in vitro and in silico Antileishmanial evaluation, antioxidant and cytotoxicity activities. J. Braz. Chem. Soc., São Paulo, v. 30, n. 11, p. 2404-2412, 2019.
Abstract: Chemotherapy treatment of leishmaniasis is based on the use of pentavalent antimonials, but these drugs present low efficacy and high toxicity. In the search for new antileishmanial agents, essential oils (EOs) from four Croton species (C. argyrophylloides, C. jacobinensis, C. nepetifolius and C. sincorensis) were evaluated against Leishmania infantum chagasi, L. amazonensis and L. braziliensis. EOs were analyzed by gas chromatography combined with mass spectrometry. Spathulenol, β-caryophyllene, β-caryophyllene oxide, 1,8-cineole and methyl eugenol were the major constituents. The evaluation of antioxidant activity by the 1,1-diphenyl-2-picryl-hydrazyl (DPPH) method showed that all EOs have moderate antioxidant activity. All oils were similarly active against L. i. chagasi, and C. nepetifolius EO showed the best result against L. amazonensis, with median inhibitory concentrations (IC50) of 9.87 μg mL-1, similar to amphotericin B (IC50 = 7.38 μg mL-1). The oils presented low cytotoxicity in macrophages. The in silico analysis revealed that spathulenol and 1,8-cineole were active against the enzyme Leishmania infantum trypanothione reductase (LiTR), showing excellent interaction energies, making them promising agents for leishmaniasis control.
URI: http://www.repositorio.ufc.br/handle/riufc/49902
metadata.dc.type: Artigo de Periódico
ISSN: 0103-5053
1678-4790 (On line)
Appears in Collections:DFIFA - Artigos publicados em revista científica

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