Please use this identifier to cite or link to this item: http://www.repositorio.ufc.br/handle/riufc/5028
Title in Portuguese: Synergistic Effect of Antituberculosis Histoplasma capsulatum var. capsulatum Drugs and Azoles In Vitro against
Author: Caetano, Érica Pacheco
Cordeiro, Rossana de Aguiar
Marques, Francisca Jakelyne de Farias
Brilhante, Raimunda Sâmia Nogueira
Silva, Kylvia Rocha de Castro e
Mourão, Charles Ielpo
Fechine, Maria Auxiliadora Bezerra
Ribeiro, Joyce Fonteles
Castelo-Branco, Débora de Souza Collares Maia
Lima, Rita Amanda Chaves de
Rocha, Jacó Ricarte Castro
Rocha, Marcos Fábio Gadelha
Sidrim, José Júlio Costa
Mesquita, Jacó Ricarte Lima
Monteiro, Andre Jalles
Keywords: Antibióticos Antituberculose
Azóis
Histoplasma
Issue Date: Jun-2011
Publisher: Antimicrobial Agents and Chemotherapy
Citation: CAETANO, E. P. et al. Synergistic Effect of Antituberculosis Drugs and Azoles In Vitro against Histoplasma capsulatum var. capsulatum . Antimicrobial Agents and Chemotherapy, Washington, v. 55, n. 9, p. 4482-84, jun. 2011.
Abstract: This study evaluated in vitro interactions of antituberculosis drugs and triazoles against Histoplasma capsulatum. Nine drug combinations, each including an antituberculosis drug (isoniazid, pyrazinamide, or ethambutol) plus a triazole (itraconazole, fluconazole, or voriconazole), were tested against both growth forms of H. capsulatum. Stronger synergistic interactions were seen in isoniazid or pyrazinamide plus triazoles for the mold form and ethambutol plus voriconazole for the yeast-like form. Further studies should evaluate these combinations in vivo.
URI: http://www.repositorio.ufc.br/handle/riufc/5028
ISSN: 0066-4804
Appears in Collections:DMC - Artigos publicados em revistas científicas

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