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Title in Portuguese: In vitro effect of Sulfamethoxazole-Trimethoprim against Histoplasma capsulatum var. capsulatum
Author: Brilhante, Raimunda Sâmia Nogueira
Fechine, Maria Auxiliadora Bezerra
Cordeiro, Rossana de Aguiar
Rocha, Marcos Fa ́bio Gadelha
Ribeiro, Joyce Fonteles
Monteiro, André Jalles
Lima, Rita Amanda Chaves de
Mesquita, Jaco ́ Ricarte Lima
Camargo, Zoilo Pires de
Sidrim, Jóse Júlio Costa
Keywords: Histoplasma
Issue Date: Sep-2010
Publisher: Antimicrobial Agents and Chemotherapy
Citation: BRILHANTE, R. S. N. et al. In vitro effect of Sulfamethoxazole-Trimethoprim against Histoplasma capsulatum var. capsulatum. Antimicrobial Agents and Chemotherapy, v. 54, n. 9, p. 3978-3979, set. 2010.
Abstract: This study evaluated the in vitro effect of sulfamethoxazole-trimethoprim against Histoplasma capsulatum var. capsulatum isolated from HIV-positive patients. The drugs were tested by microdilution testing in accordance with the CLSI guidelines. All of the strains were inhibited by sulfamethoxazole-trimethoprim, with MIC ranges of 0.039 (sulfamethoxazole)/0.0078 (trimethoprim) mg/ml to 0.625/0.125 mg/ml for mycelial forms and 0.0025/ 0.0005 to 0.02/0.004 mg/ml for yeast-like forms. However, in vivo studies are necessary to evaluate the significance of these results.
metadata.dc.type: Artigo de Periódico
ISSN: 0066-4804
Appears in Collections:DMC - Artigos publicados em revistas científicas

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