Use este identificador para citar ou linkar para este item: http://www.repositorio.ufc.br/handle/riufc/5339
Título: Prevalence of Helicobacter pylori genotypes (vacA, cagA, cagE and virB11) in gastric cancer in Brazilian’s patients : an association with histopathological parameters
Autor(es): Lima, Valeska Portela
Silva-Fernandes, Isabelle Joyce de Lima
Alves, Markênia Kélia Santos
Rabenhorst, Silvia Helena Barem
Palavras-chave: Neoplasias Gástricas
Helicobacter pylori
Data do documento: Out-2011
Editor: Cancer Epidemiology
Citação: LIMA, V. P. ; SILVA-FERNANDES, I. J. L. ; ALVES, M. K. S.; RABENHORST, S. H. B. (2011)
Abstract: Purpose: To investigate the frequency and the association of vac A alleles, cag A, cag E and vir B11 genes of Helicobacter pylori from patients with gastric cancer, considering the clinic histopathological parameters. Methods : One hundred and one gastric adenocarcinoma tissues were assessed by PCR to detect H. pylori and vac A alleles, cag A, cag E and vir B11. Results : The distribution of cases according to the presence of the genes studied showed that the group containing vac A s1m1, cag A, cag E and vir B11 H. pylori genes was significantly more frequent, followed by the group with at least one marker on the right side and left of the island. They were also present in the early stages and were the most frequent in nearly all histopathological grades. Conclusions : This study verified that vac As1m1 and cag -PAI genes, cag A, cag E and vir B11 are important H. pylori markers for gastric cancer development. Also, this study corroborates the importance of cag E and cag A together as cag -PAI marker
Descrição: LIMA, Valeska Portela; SILVA-FERNANDES, Isabelle Joyce de Lima; ALVES, Markênia Kélia Santos; RABENHORST, Silvia Helena Barem. Prevalence of Helicobacter pylori genotypes (vacA, cagA, cagE and virB11) in gastric cancer in Brazilian's patients : an association with histopathological parameters. Cancer Epidemiology, v. 35, n. 5, p. e32-e37, out. 2011.
URI: http://www.repositorio.ufc.br/handle/riufc/5339
ISSN: 0361-090X
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