Please use this identifier to cite or link to this item: http://www.repositorio.ufc.br/handle/riufc/5339
Title in Portuguese: Prevalence of Helicobacter pylori genotypes (vacA, cagA, cagE and virB11) in gastric cancer in Brazilian’s patients : an association with histopathological parameters
Author: Lima, Valeska Portela
Silva-Fernandes, Isabelle Joyce de Lima
Alves, Markênia Kélia Santos
Rabenhorst, Silvia Helena Barem
Keywords: Neoplasias Gástricas
Helicobacter pylori
Issue Date: Oct-2011
Publisher: Cancer Epidemiology
Citation: LIMA, V. P. et al. Prevalence of Helicobacter pylori genotypes (vacA, cagA, cagE and virB11) in gastric cancer in Brazilian's patients : an association with histopathological parameters. Cancer Epidemiology, v. 35, n. 5, p. e32-e37, out. 2011.
Abstract: Purpose: To investigate the frequency and the association of vac A alleles, cag A, cag E and vir B11 genes of Helicobacter pylori from patients with gastric cancer, considering the clinic histopathological parameters. Methods : One hundred and one gastric adenocarcinoma tissues were assessed by PCR to detect H. pylori and vac A alleles, cag A, cag E and vir B11. Results : The distribution of cases according to the presence of the genes studied showed that the group containing vac A s1m1, cag A, cag E and vir B11 H. pylori genes was significantly more frequent, followed by the group with at least one marker on the right side and left of the island. They were also present in the early stages and were the most frequent in nearly all histopathological grades. Conclusions : This study verified that vac As1m1 and cag -PAI genes, cag A, cag E and vir B11 are important H. pylori markers for gastric cancer development. Also, this study corroborates the importance of cag E and cag A together as cag -PAI marker
URI: http://www.repositorio.ufc.br/handle/riufc/5339
metadata.dc.type: Article
ISSN: 0361-090X
Appears in Collections:DMC - Artigos publicados em revistas científicas

Files in This Item:
File Description SizeFormat 
2011_art_vplima.pdf343,55 kBAdobe PDFView/Open


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.