Please use this identifier to cite or link to this item:
Title in Portuguese: Antitumor Effect of the Essential Oil from Leaves of Guatteria pogonopus (Annonaceae)
Author: Fontes, José Eraldo do N.
Ferraz, Rosana P. C.
Britto, Anny C. S.
Carvalho, Adriana A.
Moraes Filho, Manoel Odorico de
Pessoa, Claudia
Costa, Emmanoel V.
Bezerra, Daniel P.
Keywords: Óleos Voláteis
Issue Date: Apr-2013
Publisher: Chemistry & Biodiversity
Citation: FONTES, J. E. N. et al. Antitumor effect of the essential oil from leaves of Guatteria pogonopus (Annonaceae. Chemistry & Biodiversity, v. 10, n. 4, p. 722-729, abr. 2013.
Abstract: Guatteria pogonopus Martius , a plant belonging to the Annonaceae family, is found in the remaining Brazilian Atlantic Forest. In this study, the chemical composition and antitumor effects of the essential oil isolated from leaves of G. pogonopus was investigated. The chemical composition of the oil was determined by GC-FID and GC/MS analyses. The in vitro cytotoxicity was evaluated against three different tumor cell lines (OVCAR-8, NCI-H358M, and PC-3M), and the in vivo antitumor activity was tested in mice bearing sarcoma 180 tumor. A total of 29 compounds was identified and quantified in the oil. The major compounds were g -patchoulene (13.55%), ( E )-caryophyllene (11.36%), b -pinene (10.37%), germacrene D (6.72%), bicyclogermacrene (5.97%), a -pinene (5.33%), and germacrene B (4.69%). The essential oil, but neither ( E )-caryophyllene nor b -pinene, displayed in vitro cytotoxicity against all three tumor cell lines tested. The obtained average IC 50 values ranged from 3.8 to 20.8 m g/ml. The lowest and highest values were obtained against the NCI-H358M and the OVCAR-8 cell lines, respectively. The in vivo tumor-growth-inhibition rates in the tumor-bearing mice treated with essential oil (50 and 100 mg/kg/d) were 25.3 and 42.6%, respectively. Hence, the essential oil showed significant in vitro and in vivo antitumor activity.
metadata.dc.type: Artigo de Periódico
ISSN: 1612-1872 Impressa
1612-1880 On line
Appears in Collections:DFIFA - Artigos publicados em revista científica

Files in This Item:
File Description SizeFormat 
2013_art_aacarvalho1.pdf189,38 kBAdobe PDFView/Open

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.