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Title in Portuguese: Cardiovascular effects of Hyptis fruticosa essential oil in rats
Author: Santos, M.R.V.
Carvalho, A. A.
Medeiros, I.A.
Alves, P.B.
Marchioro, M.
Antoniolli, A.R.
Keywords: Ratos
Doenças Cardiovasculares
Issue Date: Apr-2007
Publisher: Fitoterapia
Citation: SANTOS, M. R. V. et al. Cardiovascular effects of Hyptis fruticosa essential oil in rats. Fitoterapia, Milano, v. 78, n. 3, p. 186-191, 2007.
Abstract: In non-anesthetized normotensive rats, Hyptis fruticosa essential oil (HFEO, 5, 10, 20 and 40 mg/kg; i.v.) induced hypotension associated with tachycardia. In intact and isolated rings of rat superior mesenteric artery (control), HFEO (1 – 1000 μ g/ml, n =6, cumulatively) induced concentration-dependent relaxations of tonus induced by 10 μ M phenylephrine (Phe) (pD 2 =2.6±0.27; E max =64±8.3%). In denuded endothelium pre-contracted rings with Phe or K + -depolarizing solution (80 mM), the concentration – response curves to HFEO were not shifted (pD 2 =2.3±0.25 and 2.3±0.28, respectively), but their maximal responses were significantly ( P b 0.05 vs control) increased ( E max =122.3±18.2% and 92±3.6%, respectively). HFEO was also capable of antagonizing the concentration – response curves to CaCl 2 (3 μ M – 30 mM) in a dose-dependent manner.
metadata.dc.type: Artigo
ISSN: 0367-326X
Appears in Collections:DFIFA - Artigos publicados em revista científica

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