Please use this identifier to cite or link to this item: http://www.repositorio.ufc.br/handle/riufc/5570
Title in Portuguese: Cardiovascular effects and acute toxicity of the aqueous extract of Costus spicatus leaves (Zingiberaceae)
Author: Menezes, Igor Alexandre Côrtes
Carvalho, Adriana Andrade
Antoniolli, Angelo Roberto
Santos, Márcio Roberto Viana
Keywords: Toxicidade Aguda
Zingiberaceae
Issue Date: 2007
Publisher: Biologia Geral e Experimental
Citation: MENEZES, I. A. C. ; CARVALHO, A. A. ; ANTONIOLLI, A. R. ; SANTOS, M. R. V. Cardiovascular effects and acute toxicity of the aqueous extract of Costus spicatus leaves (Zingiberaceae). Biol. Geral Exper., São Cristóvão, SE, v. 7, n. 1, p.9-13, 2007.
Abstract in Portuguese: Os efeitos cardiovasculares e a toxicidade aguda do extrato aquoso das folhas de Costus spicatus (AECS) foram estudados em ratos e camundongos. Em ratos normotensos não-anestesiados, (n = 6), AECS (0.5,1.0, 5 e 10.0 mg/kg; i.v., aleatoriamente) induziu hipotensão associado com taquicardia. Em anéis intactos ou sem endotélio da artéria mesentérica superior de rato, AECS (0.1 - 100.0 μ g/mL, n = 4) provocou relaxamento do tônus induzido por 10 μ M de fenilefrina. O extrato demonstrou baixa toxicidade aguda em camundongos
Abstract: Cardiovascular effects and acute toxicity of the aqueous extract of Costus spicatus leaves (AECS) were studied in rats and mice. In non anaesthetized normotensive rats (n = 6), AECS (0.5, 1.0, 5.0 and 10.0 mg/kg; i.v., randomly) induced hypotension associated with tachycardia. In intact or endothelium-denuded rings of rat superior mesenteric artery, AECS (0.1 - 100.0 μ g/ mL, n = 4) provoked relaxation of the tonus induced by 10 μ M phenylephrine. The extract showed low acute toxicity in mic
URI: http://www.repositorio.ufc.br/handle/riufc/5570
ISSN: 1519-1982 Impressa
1980-9689 On line
Appears in Collections:DFIFA - Artigos publicados em revista científica

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