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Title in Portuguese: Monocrotaline : histological damage and oxidant activity in brain areas of mice
Author: Honório Junior, José Eduardo Ribeiro
Vasconcelos, Germana Silva
Rodrigues, Francisca Taciana Sousa
Sena Filho, José Guedes
Barbosa-Filho, José Maria
Aguiar, Carlos Clayton Torres
Leal, Luzia Kalyne Almeida Moreira
Soares, Pedro Marcos Gomes
Woods, David John
Fonteles, Marta Maria de França
Vasconcelos, Silvânia Maria Mendes
Keywords: Monocrotalina
Issue Date: 2012
Publisher: Oxidative medicine and cellular longevity
Citation: HONÓRIO JUNIOR, J. E. R et al. Monocrotaline : histological damage and oxidant activity in brain areas of mice. Oxidative Medicine and Cellular Longevity, v. 2012, p. 1-10, 2012.
Abstract: This work was designed to study MCT effect in histopathological analysis of hippocampus (HC) and parahippocampal cortex (PHC) and in oxidative stress (OS) parameters in brain areas such as hippocampus (HC), prefrontal cortex (PFC), and striatum (ST). Swiss mice (25–30 g) were administered a single i.p. dose of MCT (5, 50, or 100 mg/kg) or 4% Tween 80 in saline (control group). After 30 minutes, the animals were sacrificed by decapitation and the brain areas (HC, PHC, PFC, or ST) were removed for histopathological analysis or dissected and homogenized for measurement of OS parameters (lipid peroxidation, nitrite, and catalase) by spectrophotometry. Histological evaluation of brain structures of rats treated with MCT (50 and 100 mg/kg) revealed lesions in the hippocampus and parahippocampal cortex compared to control. Lipid peroxidation was evident in all brain areas after administration of MCT. Nitrite/nitrate content decreased in all doses administered in HC, PFC, and ST. Catalase activity was increased in the MCT group only in HC. In conclusion, monocrotaline caused cell lesions in the hippocampus and parahippocampal cortex regions and produced oxidative stress in the HC, PFC, and ST in mice. These findings may contribute to the neurological effects associated with this compound.
metadata.dc.type: Artigo de Periódico
ISSN: 1942-0900
Appears in Collections:DFIFA - Artigos publicados em revista científica

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