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Title in Portuguese: Death-related factors in HIV/AIDS patients undergoing hemodialysis in an intensive care unit
Author: Cavalcante, Malena Gadelha
Parente, Matheus de Sá Roriz
Gomes, Pedro Eduardo Andrade de Carvalho
Meneses, Gdayllon Cavalcante
Silva Júnior, Geraldo Bezerra da
Pires Neto, Roberto da Justa
Daher, Elizabeth De Francesco
Keywords: HIV
Síndrome de Imunodeficiência Adquirida
Acquired Immunodeficiency Syndrome
Unidades de Terapia Intensiva
Intensive Care Units
Insuficiência Renal
Renal Insufficiency
Issue Date: 2021
Publisher: Revista do Instituto de Medicina Tropical de São Paulo
Citation: CAVALCANTE, Malena Gadelha et al. Death-related factors in HIV/AIDS patients undergoing hemodialysis in an intensive care unit. Rev Inst Med Trop São Paulo, v. 63, e33, 2021. Disponível em: Acesso em: 26/05/2021.
Abstract: HIV-infected patients are at high risk for developing critical diseases, including opportunistic infections (OI), with consequent admission in intensive care units (ICU). Renal disfunctions are risk factors for death in HIV/AIDS patients, and survival rates in patients undergoing hemodialysis are smaller than the ones observed in the general population. In this context, this study aimed to investigate death-related factors in HIV/AIDS patients in an intensive care setting. This is a retrospective cross-sectional study performed through the analysis of medical records from 271 HIV/AIDS-diagnosed patients hospitalized in an intensive care unit of an infectious disease hospital, in Fortaleza, Ceara State, Brazil. Patients were divided into two groups: those who underwent dialysis during hospitalization and those who did not. Clinical and demographic parameters that could be associated with death were evaluated. Results indicated a prevalence of death of 19.1% (CI 95%: 14.8-24.3). The median age of patients was 47 years, with a male predominance (71.3%). The main causes of admission were pulmonary tuberculosis (16.9%), followed by neurotoxoplasmosis (14.9%). In the bivariate analysis, for those that did not undergo dialysis, age, fever, dyspnea, oliguria, disorientation, kidney injury, use of lamivudine and efavirenz, length of hospitalization, CD4 count, WBC count, platelet count, urea, sodium and LDH levels were the associated variables. In those who needed dialysis, the use of stavudine, abacavir and ritonavir, and the length of hospitalization were associated factors. Renal toxicity by the antiretroviral agents and length of hospitalization increased the risk of death among HIV patients under dialysis.
metadata.dc.type: Artigo de Periódico
ISSN: 1678-9946
Appears in Collections:DMC - Artigos publicados em revistas científicas

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