Please use this identifier to cite or link to this item: http://www.repositorio.ufc.br/handle/riufc/6871
Title in Portuguese: Red blood cell and leukocyte alloimmunization in patients awaiting kidney transplantation
Author: Silva, Silvia Fernandes Ribeiro da
Ferreira, Gláucia Maria
Silva, Sonia Leite da
Alves, Tânia Maria de Oliveira
Ribeiro, Ilana Farias
Ribeiro, Thyciana Rodrigues
Cavalcante, Maria do Carmo Serpa
Keywords: Insuficiência Renal Crônica
Transfusão de Sangue
Transplante de Rim
Issue Date: Jun-2013
Publisher: Revista Brasileira de Hematologia e Hemoterapia
Citation: SILVA, S. F. R. et al. Red blood cell and leukocyte alloimmunization in patients awaiting kidney transplantation. Rev. Bras. Hematol Hemoter., São José do Rio Preto, SP, v. 35, n. 3, p. 185-188, jun. 2013.
Abstract: Objective: To determine the rates of red blood cell and leukocyte alloimmunization in patients with chronic kidney disease awaiting kidney transplantation. Methods: In this cross-sectional and prospective study, the serum of 393 chronic kidney disease patients on a transplant waiting list in Ceará, Northeastern Brazil were tested for red cell and leukocyte antibodies. In addition, demographic, clinical and laboratory data were collected. Results: The average age in the sample of 393 patients was 34.1 ± 14 years. Slightly more than half (208; 52.9%) were male. The average numbers of transfusions and gestations were 3.1 ± 3.3 and 1.6 ± 6, respectively. One third (33.6%) were alloimmunized: 78% with leukocyte antibodies, 9.1% with red cell antibodies and 12.9% with both. Red cell antibodies were detected in 29 cases (7.4%), 17 of whom were women, who had received more transfusions than the males (p-value < 0.0001). The most frequently detected red cell antibodies belonged to the Rh (24.1%) and Kell (13.8%) blood group systems. Leukocyte antibodies were detected in 30.5% of cases, 83 of whom were women, who had received more transfusions than the males (p-value < 0.0001) and were more reactive to panel reactive antibodies (p-value < 0.0001). The mean alloreactivity to panel reactive antibodies was 47.7 ± 31.2%. Conclusion: Chronic kidney disease patients on the transplant waiting list in Ceará, Brazil, display high rates of red cell (7.4%) and leukocyte (30.5%) alloimmunization. In this sample, alloimmunization was significantly associated with the number of transfusions and gender.
URI: http://www.repositorio.ufc.br/handle/riufc/6871
metadata.dc.type: Artigo de Periódico
ISSN: 1516-8484
Appears in Collections:DCOD - Artigos publicados em revistas científicas

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