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Title in Portuguese: Genotyping and drug resistance patterns of Mycobacterium tuberculosis strains observed in a tuberculosis high-burden municipality in Northeast, Brazil
Author: Luiza, Roberta dos Santos Silva
Suffys, Phillip
Barroso, Elizabeth Clara
Kerr, Ligia Regina Franco Sansigolo
Duarte, Cynthia Romariz
Freitas, Max Victor Carioca
Mota, Rosa Maria Salani
Frota, Cristiane Cunha
Keywords: Tuberculose
Resistência a Medicamentos
Issue Date: May-2013
Publisher: The Brazilian Journal of Infectious Diseases
Citation: LUIZA, R. S. S. et al. Genotyping and drug resistance patterns of Mycobacterium tuberculosis strains observed in a tuberculosis high-burden municipality in Northeast, Brazil. The Brazilian Journal of Infectious Diseases, Salvador, BA, v. 17, n. 3, p. 338-345, maio/jun. 2013
Abstract: Objectives: This study has used a combination of clinical information, spoligotyping, and georeferencing system to elucidate the genetic diversity of the Mycobacterium tuberculosis isolates circulating in a TB-prevalent municipality of Northeast Brazil. Methods: A total of 115 M. tuberculosis strains were isolated from pulmonary tuberculosis patients from January 2007 to March 2008 in Fortaleza. Drug susceptibility and spoligotyping assays were performed and place of residence of the patients were georeferenced. Results: Of the M. tuberculosis strains studied, 51 (44.3%) isolateswere resistant to at least one drug (R-TB) and 64 (55.7%) were sensitive to all the drugs tested (S-TB). A high frequency of resistancewas found in previously treated cases (84%) and among newcases (16%; p < 0.001). A total of 74 (64%) isolates were grouped into 22 spoligotyped lineages, while 41 (36%) isolates were identified as new. Among the predominant genotypes, 33% were Latim American Mediterranean (LAM), 12% Haarlem (H), and 5% U. There was no association of geographic distribution of RT-TB patients as compared to the controls and also the geographic location to the spoligotype patterns. The geospatial analysis revealed that 24 (23%) patients (hot spot zones) either shared the same residence or lived in a close neighborhood of a case. Among these concentration zones, the patients lived in the same residence and shared a common genotype pattern and resistance pattern. Discussion: It was observed that the spoligopatterns family distribution was similar to that reported for South America, prevailing the LAM and H lineages. A high rate-case among the resistant TB group occurs as a result of transmitted and acquired resistance.Amore effective surveillance program is needed in order to succeed in reducing tuberculosis in Northeast Brazil.
metadata.dc.type: Artigo de Periódico
ISSN: 1413-8670 Print
Appears in Collections:PPGSP - Artigo publicado em revista científica

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