Please use this identifier to cite or link to this item: http://www.repositorio.ufc.br/handle/riufc/7191
Title in Portuguese: A new approach for the synthesis of 3-substituted cytotoxic Nor-β-Lapachones
Author: Cardoso, Mariana F. C.
Silva, Illana M. C. B. da
Santos Júnior, Helvécio M. dos
Rocha, David R.
Araújo, Ana Jérsia
Pessoa, Claudia
Moraes Filho, Manoel Odorico de
Lotufo, Letícia V. C.
Silva, Fernando de C.
Santos, Wilson C.
Ferreira, Vitor F.
Keywords: Carboidratos
Naftoquinonas
Issue Date: 2013
Publisher: Journal of the Brazilian Chemical Society
Citation: CARDOSO, M. F. C. et al. A new approach for the synthesis of 3-Substituted cytotoxic Nor-β-Lapachones. J. Braz. Chem. Soc., São Paulo, v. 24, n. 1, p. 12-16, 2013.
Abstract in Portuguese: Vários estudos têm mostrado o potencial citotóxico de derivados da nor-β-lapachona contra células tumorais. Considerando a nor-β-lapachona um importante protótipo, uma série inédita de nor-β-lapachonas substituídas em C-3 foi sintetizada através de uma nova metodologia sintética envolvendo intermediário sintético 3-hidróxi-nor-β-lapachona para o acoplamento de alguns nucleófilos contendo núcleos derivados de carboidratos ou 2H-pirazóis. Todos os derivados foram avaliados frente a quatro linhagens de células tumorais. Duas das substâncias apresentaram moderada citotoxicidade, enquanto as demais inibiram fortemente todas as linhagens tumorais testadas.
Abstract: Several studies have demonstrated the cytotoxic potential of nor-β-lapachone derivative against cancer cells. Considering nor-β-lapachone as an important prototype, a set of new 3-substituted nor-β-lapachones was synthesized by a new synthetic route that involves the use of synthetic intermediate generated for coupling with several nucleophiles containing the carbohydrate and 2H-pyrazole substituent moieties. All the compounds were screened against four tumor cell lines. Two of the compounds showed moderate cytotoxicity, while the other compounds strongly inhibit all tested cancer cell lines.
URI: http://www.repositorio.ufc.br/handle/riufc/7191
metadata.dc.type: Artigo de Periódico
ISSN: 0103-5053 Impresso
1678-4790 On-line
Appears in Collections:DFIFA - Artigos publicados em revista científica

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