Please use this identifier to cite or link to this item: http://www.repositorio.ufc.br/handle/riufc/7193
Title in Portuguese: Trachylobane and kaurane diterpenes from Croton floribundus Spreng
Author: Uchôa, Paula Karina S.
Silva Jr., José Nunes da
Silveira, Edilberto Rocha
Lima, Mary Anne S.
Braz-Filho, Raimundo
Costa-Lotufo, Letícia Veras
Araújo, Ana Jérsia
Moraes, Manoel Odorico de
Pessoa, Claudia do Ó
Keywords: Diterpenos
Euphorbiaceae
Issue Date: 2013
Publisher: Química Nova
Citation: UCHÔA, P. K. S. et al. Trachylobane and kaurane diterpenes from Croton floribundus Spreng. Química Nova, São Paulo, v. 36, n. 6, p. 778-782, 2013.
Abstract: A new trachylobane diterpene ent-trachyloban-18,19-diol (1) was isolated from root bark of Croton floribundus, along with known diterpenes ent-trachyloban-19-oic acid (2), 15b-hydroxy-ent-trachyloban-19-oic acid (3), ent-trachyloban-19-ol (4), ent-kaur-16-en- 19-oic acid (5), ent-kaur-16-ene-6a,19-diol (6) and ent-16a-hydroxykaur-11-en-19-oic acid (7). ent-trachyloban-18,19-diol (1) was submitted to derivatization reactions affording four new compounds (8-11). Cytotoxic activity of diterpenes 1, 3, 4, 7-11 against three human cancer cell lines was evaluated. No compounds showed cytotoxic potential with IC50 values greater than 25 mg/mL. Compound 6 was evaluated against five human cancer cell lines, showing moderate effect against three cancer cell lines, MDA-MB-435, HCT-8 and HCT-116, with IC50 values of 14.32, 13.47 and 12.1 mg/mL, respectively.
URI: http://www.repositorio.ufc.br/handle/riufc/7193
ISSN: 0100-4042
Appears in Collections:DFIFA - Artigos publicados em revista científica

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