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|Title in Portuguese:||Trachylobane and kaurane diterpenes from Croton floribundus Spreng|
|Author:||Uchôa, Paula Karina S.|
Silva Jr., José Nunes da
Silveira, Edilberto Rocha
Lima, Mary Anne S.
Costa-Lotufo, Letícia Veras
Araújo, Ana Jérsia
Moraes, Manoel Odorico de
Pessoa, Claudia do Ó
|Citation:||UCHÔA, P. K. S. et al. Trachylobane and kaurane diterpenes from Croton floribundus Spreng. Química Nova, São Paulo, v. 36, n. 6, p. 778-782, 2013.|
|Abstract:||A new trachylobane diterpene ent-trachyloban-18,19-diol (1) was isolated from root bark of Croton floribundus, along with known diterpenes ent-trachyloban-19-oic acid (2), 15b-hydroxy-ent-trachyloban-19-oic acid (3), ent-trachyloban-19-ol (4), ent-kaur-16-en- 19-oic acid (5), ent-kaur-16-ene-6a,19-diol (6) and ent-16a-hydroxykaur-11-en-19-oic acid (7). ent-trachyloban-18,19-diol (1) was submitted to derivatization reactions affording four new compounds (8-11). Cytotoxic activity of diterpenes 1, 3, 4, 7-11 against three human cancer cell lines was evaluated. No compounds showed cytotoxic potential with IC50 values greater than 25 mg/mL. Compound 6 was evaluated against five human cancer cell lines, showing moderate effect against three cancer cell lines, MDA-MB-435, HCT-8 and HCT-116, with IC50 values of 14.32, 13.47 and 12.1 mg/mL, respectively.|
|Appears in Collections:||DFIFA - Artigos publicados em revista científica|
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