Please use this identifier to cite or link to this item: http://www.repositorio.ufc.br/handle/riufc/7197
Title in Portuguese: Anti-inflammatory effect of a sulphated polysaccharide fraction extracted from the red algae Hypnea musciformis via the suppression of neutrophil migration by the nitric oxide signalling pathway
Author: Brito, Tarcisio Vieira de
Prudêncio, Rafael da Silva
Sales, Adriano Bezerra
Vieira Júnior, Francisco das Chagas
Candeira, Starley Jone Nogueira
Franco, Álvaro Xavier
Aragão, Karoline Sabóia
Ribeiro, Ronaldo de Albuquerque
Souza, Marcellus Henrique Loiola Ponte de
Chaves, Luciano de Sousa
Freitas, Ana Lúcia Ponte
Medeiros, Jand-Venes Rolim
Barbosa, André Luiz dos Reis
Keywords: Óxido Nítrico
Rodófitas
Issue Date: May-2013
Publisher: Journal of Pharmacy and Pharmacology
Citation: BRITO, T. V. de et al. Anti-inflammatory effect of a sulphated polysaccharide fraction extracted from the red algae Hypnea musciformis via the suppression of neutrophil migration by the nitric oxide signalling pathway. Journal of Pharmacy and Pharmacology, London, GB, v. 65, n. 5, p. 724–733, maio, 2013.
Abstract: Objectives The aim of this study was to evaluate the anti-inflammatory effect of a sulphated polysaccharide fraction (PLS) extracted from the alga Hypnea musciformis and investigate the possible involvement of the nitric oxide (NO) pathway in this effect. Methods The anti-inflammatory activity of PLS was evaluated using inflammatory agents (carrageenan and dextran) to induce paw oedema and peritonitis in Swiss mice. Samples of paw tissue and peritoneal fluid were removed to determine myeloperoxidase (MPO) activity, NO3/NO2 levels, and interleukin-1b (IL-1b) level. The involvement of NO in the modulation of neutrophil migration in carrageenan-induced paw oedema or peritonitis was also investigated. Key findings Compared with vehicle-treated mice, mice pretreated with PLS (10 mg/kg) inhibited carrageenan-induced and dextran-induced oedema; it also inhibited total and differential peritoneal leucocyte counts in a model of peritonitis. These PLS effects were reversed by l-arginine treatment and recovered with the administration of a NO synthase blocker (aminoguanidine). Furthermore, PLS reduced the MPO activity, decreased IL-1b levels, and increased NO3/NO2 levels in the peritoneal cavity. Conclusions PLS reduced the inflammatory response by modulating neutrophil migration, which appeared to be dependent on the NO pathway.
URI: http://www.repositorio.ufc.br/handle/riufc/7197
metadata.dc.type: Artigo de Periódico
ISSN: 2042-7158 Online
Appears in Collections:DFIFA - Artigos publicados em revista científica

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