Please use this identifier to cite or link to this item: http://www.repositorio.ufc.br/handle/riufc/7243
Title in Portuguese: Effects of the ethanol extract of the inner bark of Syderoxylum obtusifolium in the cyclophosphamide-induced cystitis in rats
Author: Pereira, Denyson Santana
Morais, Janaína Pereira
Santana, Danielle Gomes
Santos, Cliomar Alves
Thomazzi, Sara Maria
Santos, Charles Estevam dos
Antoniolli, Angelo Roberto
Bezerra, Daniel Pereira
Camargo, Enilton Aparecido
Keywords: Ciclofosfamida
Cistite
Issue Date: May-2013
Publisher: Journal of Medicinal Plants Research
Citation: PEREIRA, D. S. et al. Effects of the ethanol extract of the inner bark of Syderoxylum obtusifolium in the cyclophosphamide-induced cystitis in rats. Journal of Medicinal Plant Research, v. 7, n. 20, p. 1411-1417, maio, 2013.
Abstract: In this study, the ethanol extract of the inner bark of the Syderoxylum obtusifolium (EESob) was tested in the model of cyclophosphamide-induced hemorrhagic cystitis. Male Wistar rats were submitted to the injection of cyclophosphamide, 1 h after the treatment with EESob (200 or 400 mg/kg) or vehicle. After 24 h, the urinary bladder was excised and the edema, myeloperoxidase activity and malondialdehyde formation were measured. Also, myeloperoxidase activity and malondialdehyde formation in lung, spleen and liver and leukocyte counts in the peripheral blood were evaluated. Injection of cyclophosphamide increased myeloperoxidase activity and edema. The former was inhibited by the EESob at 400 mg/kg, but the latter was not affected. Although cyclophosphamide did not alter the bladder malondialdehyde formation, pre-treatment with EESob at both doses markedly increased this parameter. Lung and liver parameters or leukocyte counts were not altered by EESob. The spleen myeloperoxidase activity and malondialdehyde formation were not affected by cyclophosphamide, but were increased by the treatment with EESob. These results suggests that EESob administration to rats decrease myeloperoxidase activity in bladder tissue, but is accompanied by lipoperoxidation in this tissue, as well as in spleen, which do not support the use of EESob to treat cystitis.
URI: http://www.repositorio.ufc.br/handle/riufc/7243
metadata.dc.type: Artigo de Periódico
ISSN: 1996-0875
Appears in Collections:DFIFA - Artigos publicados em revista científica

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