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|Title in Portuguese:||Prevention and reversal of ketamine-induced schizophrenia related behavior by minocycline in mice : possible involvement of antioxidant and nitrergic pathways|
|Author:||Monte, Aline Santos|
Souza, Greicy Coelho de
McIntyre, Roger S.
Soczynska, Joanna K.
Santos, Júnia Vieira dos
Cordeiro, Rafaela Carneiro
Ribeiro, Bruna Mara Machado
Lucena, David Freitas de
Vasconcelos, Silvânia Maria Mendes
Sousa, Francisca Cléa Florenço de
Carvalho, André Férrer
Macêdo, Danielle S.
|Publisher:||Journal of Psychopharmacology|
|Citation:||MONTE, A. S. et al. Prevention and reversal of ketamine-induced schizophrenia related behavior by minocycline in mice : possible involvement of antioxidant and nitrergic pathways. Journal of Psychopharmacology, Oxford, v. 27, n. 11, p. 1032-43, nov., 2013.|
|Abstract:||It has been hypothesized that oxidative imbalance and alterations in nitrergic signaling play a role in the neurobiology of schizophrenia. Preliminary evidence suggests that adjunctive minocycline treatment is efficacious for cognitive and negative symptoms of schizophrenia. This study investigated the effects of minocycline in the prevention and reversal of ketamine-induced schizophrenia-like behaviors in mice. In the reversal protocol, animals received ketamine (20 mg/kg per day intraperitoneally or saline for 14 days, and minocycline (25 or 50 mg/kg daily), risperidone or vehicle treatment from days 8 to 14. In the prevention protocol, mice were pretreated with minocycline, risperidone or vehicle prior to ketamine. Behaviors related to positive (locomotor activity and prepulse inhibition of startle), negative (social interaction) and cognitive (Y maze) symptoms of schizophrenia were also assessed. Glutathione (GSH), thiobarbituric acid-reactive substances (TBARS) and nitrite levels were measured in the prefrontal cortex, hippocampus and striatum. Minocycline and risperidone prevented and reversed ketamine-induced alterations in behavioral paradigms, oxidative markers (i.e. ketamine-induced decrease and increase in GSH levels and TBARS content, respectively) as well as nitrite levels in the striatum. These data provide a rationale for evaluating minocycline as a novel psychotropic agent and suggest that its mechanism of action includes antioxidant and nitrergic systems.|
|metadata.dc.type:||Artigo de Periódico|
|Appears in Collections:||DENF - Artigos publicados em revistas científicas|
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