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Title in Portuguese: Time course of the effects of lipopolysaccharide on prepulse inhibition and brain nitrite content in mice
Author: Custódio, Charllyany Sabino
Mello, Bruna Stefânia Ferreira
Cordeiro, Rafaela Carneiro
Araújo, Fernanda Yvelize Ramos de
Chaves, João Henrique
Vasconcelos, SilvâniaMaria Mendes
Nobre Júnior, Hélio Vitoriano
Sousa, Francisca Cléa Florenço de
Vale, Mariana Lima
Carvalho, André Férrer
Macêdo, Danielle Silveira
Keywords: Óxido Nítrico
Issue Date: Aug-2013
Publisher: European Journal of Pharmacology
Citation: CUSTÓDIO, C. S. et al. Time course of the effects of lipopolysaccharide on prepulse inhibition and brain nitrite content in mice. European Journal of Pharmacology, Amsterdan, v. 713, p. 31-38, out. 2013.
Abstract: The systemic administration of lipopolysaccharide (LPS) induces time-dependent behavioral alterations, which are related to sickness behavior and depression. The time-course effects of LPS on prepulse inhibition (PPI) remain unknown. Furthermore, the time-dependent effects of LPS on central nitrite content had not been investigated. Therefore, we studied alterations induced by single LPS (0.5 mg/kg, i.p.) administration to mice on parameters, such as PPI, depressive- and anxiety-like behaviors, working memory, locomotor activity and motor coordination, 1.5 and 24 h post-LPS administration. IL-1 β and TNF α in the blood and brain as well as brain nitrite levels were evaluated in the prefrontal cortex (PFC), hippocampus (HC) and striatum (ST). An overall hypolocomotion was observed 1.5 h post-LPS, along with depressive-like behaviors and de fi cits in working memory. Increments in IL-1 β content in plasma and PFC, TNF α in plasma and decreases in nitrite levels in the ST and PFC were also veri fi ed. Twenty-four hours post-LPS treatment, depressive-like behaviors and working memory de fi cits persisted, while PPI levels signi fi cantly reduced along with increases in IL-1 β content in the PFC and a decrease in nitrite levels in the HC, ST and PFC. Our data demonstrate that a delayed increase (i.e., 24 h post-LPS) in PPI levels ensue, which may be useful behavioral parameter for LPS-induced depression. A decrease in nitrergic neurotransmission was associated with these behavioral fi ndings
metadata.dc.type: Artigo de Periódico
ISSN: 0014-2999
Appears in Collections:DMC - Artigos publicados em revistas científicas

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