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Title in Portuguese: Evaluation of the anti-inflammatory activity of riparin II (O-methil- N-2-hidroxi-benzoyl tyramine) in animal models
Author: Carvalho, Alyne Mara Rodrigues de
Rocha, Nayrton Flávio Moura
Vasconcelos, Leonardo Freire
Rios, Emiliano Ricardo Vasconcelos
Dias, Marília Leite
Silva, Maria Izabel Gomes
Fonteles, Marta Maria de França
Barbosa Filho, José Maria
Chavez Gutierrez, Stanley Juan
Sousa, Francisca Cléa Florenço de
Keywords: Dor
Issue Date: 2013
Publisher: Chemico-Biological Interactions
Citation: CARVALHO, A. M. R. de et al. Evaluation of the anti-inflammatory activity of riparin II (O-methil-N-2-hidroxi-benzoyl tyramine) in animal models. Chemico-Biological Interactions, v. 205, n. 3, p. 165-172, 2013.
Abstract: Riparin II (RipII), an alkamide isolated from the green fruit of Aniba riparia, was tested in the various animal models of inflammation to investigate its anti-inflammatory activity. Male Wistar rats (180–240 g) were treated with RipII by gavage at doses 25 or 50 mg/kg, before initiating the inflammatory responses. The tests used were paw edema induced by carrageenan, dextran, histamine or serotonin; peritonitis induced by carrageenan and fMLP, as well as the measurement of MPO activity, TNF-a and Il-1b amount in the peritoneal fluid. In the animal models of carrageenan and dextran-induced paw edema, the animals treated with RipII showed lower edema than those of the control group. Treatment with RipII also reduced the paw edema induced by histamine but not serotonin. In the carrageenan-induced peritonitis model, treatment with RipII reduced leukocyte migration, the MPO activity and the amount of TNF-a and IL-1b in the peritoneal fluid. In summary, these results indicate that RipII has an anti-inflammatory activity in chemical models of acute inflammation. RipII might be directly or indirectly inhibiting the activity, production or release of pro-inflammatory mediators involved in the generation of the pain associated with inflammation.
metadata.dc.type: Artigo de Periódico
ISSN: 0009-2797
Appears in Collections:DFIFA - Artigos publicados em revista científica

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