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|Título:||Structural brain abnormalities in patients with Parkinson’s disease with visual hallucinations : a comparative voxel-based analysis|
|Autor(es):||Gama, Romulo Lopes|
Bruin, Veralice Meireles Sales
Távora, Daniel Gurgel Fernandes
Duran, Fábio L.S.
|Palavras-chave:||Doença de Parkinson|
|Data do documento:||Jun-2014|
|Editor:||Brain and Cognition|
|Citação:||GAMA, R. L. ; BRUIN, V. M. S. ; TÁVORA, D. G. F. ; DURAN, F. L.S. ; BITTENCOURT, L. ; TUFIK, S. (2014)|
|Abstract:||The objective is to evaluate clinical characteristics and cerebral alterations in Parkinson’s disease (PD) patients with diurnal visual hallucinations (VHs). Assessment was performed using magnetic resonance image (MRI) and voxel-based morphometry (VBM). Thirty-nine patients with PD (53.8%) and ten controls were studied. Voxel based morphology analysis was performed. Eleven patients presented diurnal VHs and among these, six had cognitive dysfunction. Patients with VHs performed worse in the mentationrelated UPDRS I (p = 0.005) and motor-related UPDRS III (p = 0.02). Patients with VHs showed significant clusters of reduced grey matter volume compared to controls in the left opercula frontal gyrus and left superior frontal gyrus. PD without hallucinations demonstrated reduced grey matter volume in the left superior frontal gyrus compared to controls. Comparisons between patients with VHs regarding the presence of cognitive dysfunction showed that cases with cognitive dysfunction as compared to those without cognitive dysfunction showed significant clusters of reduced grey matter volume in the left opercular frontal gyrus. Cases without cognitive dysfunction had reduced grey matter substance in the left insula and left trigonal frontal gyrus. Judging from our findings, an abnormal frontal cortex, particularly left sided insula, frontal opercular, trigonal frontal gyrus and orbital frontal would make PD patients vulnerable to hallucinations. Compromise of the left operculum distinguished cases with VHs and cognitive dysfunction. Our findings reinforce the theoretical concept of a top-down visual processing in the genesis of VHs in PD.|
|Descrição:||GAMA, Rômulo Lopes ; BRUIN, Veralice Meireles Sales ; TÁVORA, Daniel Gurgel Fernandes ; DURAN, Fábio L.S. ; BITTENCOURT, Lia ; TUFIK, Sergio. Structural brain abnormalities in patients with Parkinson’s disease with visual hallucinations : a comparative voxel-based analysis. Brain and Cognition, New York, v. 87, p. 97-103, jun. 2014.|
|Aparece nas coleções:||DMC - Artigos publicados em revistas científicas|
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